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CUEDC1 CUE domain containing 1 [ Homo sapiens (human) ]

Gene ID: 404093, updated on 2-Nov-2024

Summary

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Official Symbol
CUEDC1provided by HGNC
Official Full Name
CUE domain containing 1provided by HGNC
Primary source
HGNC:HGNC:31350
See related
Ensembl:ENSG00000180891 MIM:620552; AllianceGenome:HGNC:31350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin binding activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 6.5), brain (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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See CUEDC1 in Genome Data Viewer
Location:
17q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (57861243..57955412, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58734503..58828695, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55938604..56032773, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 94 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55887988-55888874 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910113-55910624 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910625-55911135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55911304-55911804 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55923593-55924200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55927391-55927900 Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55937722-55938572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55938573-55939422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55939423-55940272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:55945275-55946474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951125-55951765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951766-55952407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953049-55953690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953691-55954331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55956376-55956928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958036-55958588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958589-55959141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55962626-55963126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55969929-55970670 Neighboring gene Sharpr-MPRA regulatory region 2303 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55977227-55977897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12452 Neighboring gene uncharacterized LOC107985065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55991179-55991679 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:56004573-56005088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12454 Neighboring gene Sharpr-MPRA regulatory region 4150 Neighboring gene Sharpr-MPRA regulatory region 6256 Neighboring gene NANOG hESC enhancer GRCh37_chr17:56029838-56030339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56043109-56043617 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:56046907-56047067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8755 Neighboring gene uncharacterized LOC101929185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12456 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12457 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:56082218-56083417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12459 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56084242-56084960 Neighboring gene serine and arginine rich splicing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M(3))]. Zhuang WC, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020 Oct. PMID 33067938
  2. CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer. Cui Y, et al. Aging (Albany NY), 2020 Oct 25. PMID 33099540, Free PMC Article
  3. CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells. Lopes R, et al. Cancer Lett, 2018 Nov 1. PMID 30145202
  4. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Baranzini SE, et al. Brain, 2010 Sep. PMID 20802204, Free PMC Article
  5. Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Lim SK, et al. Cancer Res, 2016 Nov 1. PMID 27578003

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CUEDC1 inhibits epithelial-mesenchymal transition via the TbetaRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.
    Title: CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.
  2. [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M3)].
    Title: [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M(3))].
  3. Data inidicate CUE domain containing 1 (CUEDC1) expression correlates positively with estrogen receptor alpha (ERalpha) in breast cancer, and suggest CUEDC1 is a functional target gene of ERalpha and is required for breast cancer cell proliferation.
    Title: CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20739, DKFZp547L163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271875.2 → NP_001258804.1  CUE domain-containing protein 1

    See identical proteins and their annotated locations for NP_001258804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC015813, AC015845, AK000746, BC056882, BG475111, BU732837
    Consensus CDS
    CCDS11599.1
    UniProtKB/Swiss-Prot
    D3DTZ2, Q9NWD0, Q9NWM3
    Related
    ENSP00000462717.1, ENST00000577830.6
    Conserved Domains (1) summary
    cd14366
    Location:46 → 87
    CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

  2. NM_001292025.2 → NP_001278954.1  CUE domain-containing protein 1

    See identical proteins and their annotated locations for NP_001278954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC015845, AK000746, BC056882, BU732837, CR627470
    Consensus CDS
    CCDS11599.1
    UniProtKB/Swiss-Prot
    D3DTZ2, Q9NWD0, Q9NWM3
    Related
    ENSP00000353373.2, ENST00000360238.6
    Conserved Domains (1) summary
    cd14366
    Location:46 → 87
    CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    57861243..57955412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024641.3 → XP_016880130.1  CUE domain-containing protein 1 isoform X2

  2. XM_047436060.1 → XP_047292016.1  CUE domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DTZ2, Q9NWD0, Q9NWM3

  3. XM_011524812.3 → XP_011523114.1  CUE domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    J3QLQ8
    Related
    ENSP00000463666.1, ENST00000577840.5

RNA

  1. XR_934459.4 RNA Sequence

  2. XR_934460.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    58734503..58828695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316112.1 → XP_054172087.1  CUE domain-containing protein 1 isoform X2

  2. XM_054316111.1 → XP_054172086.1  CUE domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3DTZ2, Q9NWD0, Q9NWM3

  3. XM_054316113.1 → XP_054172088.1  CUE domain-containing protein 1 isoform X3

RNA

  1. XR_008484819.1 RNA Sequence

  2. XR_008484820.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWM3.1 GenPept UniProtKB/Swiss-Prot:Q9NWM3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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