CAV1 caveolin 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CAV1provided by VGNC
Official Full Name: caveolin 1provided by VGNC
Primary source: VGNC:VGNC:38751
See related: Ensembl:ENSCAFG00845006847
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (55500946..55536541)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (54856462..54888069)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (55590528..55622125)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (55530973..55562566)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (55219411..55251015)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caveolin-1 and ERK1/2 can be used as a new therapeutic target for the treatment of arteriovenous fistula dysfunction.
Title: Effects of Caveolin-1-ERK1/2 pathway on endothelial cells and smooth muscle cells under shear stress.
Cav1-dependent repression of Fzd2 and exosome uptake is potentially relevant to its antitransformation activity, which hinders the activation of Ha-Ras(V12) -Wnt5a-Stat3 pathway.
Title: Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-Ras(V12) -induced cell transformation.
results demonstrate that knockdown of EPLIN or Cav-1 substantially suppresses apical extrusion of transformed cells, implying that the expression of these molecules is required for the elimination of newly emerging transformed cells from the epithelium.
Title: EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Early intervertebral disc degeneration involves down-regulation of Caveolin-1 expression
Title: Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.
To better understand the role of caveolin-1 in bone homeostasis and response to beta-TCP scaffold, beta-TCP was implanted into mandible defects, and gene expression profiles were examined focused on the molecular components involved in caveolin-1 regulation.
Title: Expression of caveolin-1 in the early phase of beta-TCP implanted in dog mandible.
Malignant mammary cells showed a loss of Cav-1 expression. Our findings indicate that Cav-1 is a potential prognostic marker for canine mammary tumors.
Title: Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors.
Alcohol promotes the myocardial oxidative stress and fibrosis through an elevated expression of PYK2 and a lowered expression of caveolin-1.
Title: [Roles of PYK2 and caveolin-1 in alcoholic cardiomyopathy and the effect of drug intervention].
Diminished function of human BCRP transfected into MDCK cells after canine Cav1 knockdown is likely mediated by alterations in protein-protein interactions and suggests a positive regulation of BCRP function by CAV1.
Title: Knockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivity.
these is a strong correlation between Cav-1-positive breast carcinomas and shorter overall survival in dogs.
Title: Caveolin-1 in diagnosis and prognosis of canine mammary tumours: comparison of evaluation systems.
RNAi-mediated Cav-1 knock-down results in a decrease in virus titre in infected Madin-Darby canine kidney cells.
Title: Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell culture.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in caveola assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caveolin-1

Names: vesicular integral-membrane protein VIP21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003296.1 → NP_001003296.1 caveolin-1

See identical proteins and their annotated locations for NP_001003296.1

Status: PROVISIONAL

Source sequence(s)

U47060

UniProtKB/Swiss-Prot

A0M8U8, P33724

UniProtKB/TrEMBL

A0A8C0K0N3, A0A8C0MMY6, A0A8I3N6T8

Related

ENSCAFP00845009515.1, ENSCAFT00845012174.1

Conserved Domains (1) summary

pfam01146
Location:45 → 175

Caveolin

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051818.1 Reference ROS_Cfam_1.0

Range

55500946..55536541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038685937.1 → XP_038541865.1 caveolin-1 isoform X1

UniProtKB/TrEMBL

A0A8C0MMY6, A0A8I3N6T8

Conserved Domains (1) summary

pfam01146
Location:14 → 144

Caveolin
XM_038685936.1 → XP_038541864.1 caveolin-1 isoform X1

UniProtKB/TrEMBL

A0A8C0MMY6, A0A8I3N6T8

Conserved Domains (1) summary

pfam01146
Location:14 → 144

Caveolin