GH1 growth hormone [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: GH1
Gene description: growth hormone
See related: Ensembl:ENSCAFG00845021230
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GH; GHB1
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Genomic context

Location:: chromosome: 9

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (13493565..13499392, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (12791907..12793764, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (15092601..15094459)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (12440328..12442183, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (15090131..15091987)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs.
Title: Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs.
Study provides evidence that progesteron might increase autocrine Growth Hormone production which might directly stimulate local or systemic IGF-I secretion in canine mammary tumours.
Title: Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17beta-estradiol) in canine mammary tumours.
Progesterone alone has no direct stimulatory effect on GH transcription in mammary gland.
Title: Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells.

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General gene information

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Markers

GH1 (e-PCR), detects polymorphism
- UniSTS:264033

GHI (e-PCR)
- UniSTS:266722

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of growth	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: somatotropin

Names: growth hormone 1; growth hormone B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003168.1 → NP_001003168.1 somatotropin precursor

See identical proteins and their annotated locations for NP_001003168.1

Status: PROVISIONAL

Source sequence(s)

AF069071

UniProtKB/Swiss-Prot

P33711, Q9TQT6

UniProtKB/TrEMBL

A0A0M6L0Q5, A0A8C0R8H6

Related

ENSCAFP00845029397.1, ENSCAFT00845037520.1

Conserved Domains (1) summary

cd10285
Location:35 → 214

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

13493565..13499392 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038674956.1 → XP_038530884.1 somatotropin isoform X1

Conserved Domains (1) summary

cd10285
Location:35 → 220

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
XM_038674955.1 → XP_038530883.1 somatotropin isoform X1

Conserved Domains (1) summary

cd10285
Location:35 → 220

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
XM_038674957.1 → XP_038530885.1 somatotropin isoform X2

UniProtKB/TrEMBL

A0A8C0SZP6, A0A8I3PMN1

Related

ENSCAFP00845029443.1, ENSCAFT00845037580.1

Conserved Domains (1) summary

cd10285
Location:35 → 175

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
XM_038674958.1 → XP_038530886.1 somatotropin isoform X3

Conserved Domains (1) summary

cd10285
Location:35 → 151

somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones