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ppara.S peroxisome proliferator activated receptor alpha S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398843, updated on 4-Nov-2024

Summary

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Official Symbol
ppara.S
Official Full Name
peroxisome proliferator activated receptor alpha S homeolog
Primary source
Xenbase:XB-GENE-17339020
Locus tag
XELAEV_18019740mg
See related
EnsemblRapid:ENSXLAG00005000228 AllianceGenome:Xenbase:XB-GENE-17339020
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nr1c1; ppara; xppara; PPARalpha; xPPARalpha
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of cholesterol storage; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ppara.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (1708406..1725456, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (1706878..1723655, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 1 S homeolog Neighboring gene uncharacterized LOC121402085 Neighboring gene malonyl-CoA-acyl carrier protein transacylase S homeolog Neighboring gene uncharacterized LOC121402086 Neighboring gene uncharacterized LOC121402087

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. Krey G, et al. J Steroid Biochem Mol Biol, 1993 Dec. PMID 8274443
  2. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Dreyer C, et al. Cell, 1992 Mar 6. PMID 1312391
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68537

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor alpha
Names
PPAR-alpha
nuclear receptor subfamily 1 group C member 1
xPPAR alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089813.1 → NP_001083282.1  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_001083282.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060004
    UniProtKB/Swiss-Prot
    P37232
    UniProtKB/TrEMBL
    Q6PAY0
    Conserved Domains (2) summary
    cd06932
    Location:208 → 473
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    1708406..1725456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041587556.1 → XP_041443490.1  peroxisome proliferator-activated receptor alpha isoform X3

    UniProtKB/TrEMBL
    A0A8J1MR19
    Conserved Domains (2) summary
    cd06932
    Location:108 → 373
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:76 → 91
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. XM_041587555.1 → XP_041443489.1  peroxisome proliferator-activated receptor alpha isoform X2

    UniProtKB/TrEMBL
    A0A8J1MNX3
    Conserved Domains (2) summary
    cd06932
    Location:132 → 397
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:55 → 115
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  3. XM_041587552.1 → XP_041443486.1  peroxisome proliferator-activated receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    P37232
    UniProtKB/TrEMBL
    A0A974D847, Q6AXA9
    Conserved Domains (2) summary
    cd06932
    Location:208 → 473
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  4. XM_041587553.1 → XP_041443487.1  peroxisome proliferator-activated receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    P37232
    UniProtKB/TrEMBL
    A0A974D847, Q6AXA9
    Conserved Domains (2) summary
    cd06932
    Location:208 → 473
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  5. XM_041587554.1 → XP_041443488.1  peroxisome proliferator-activated receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    P37232
    UniProtKB/TrEMBL
    A0A974D847, Q6AXA9
    Conserved Domains (2) summary
    cd06932
    Location:208 → 473
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

  6. XM_041587551.1 → XP_041443485.1  peroxisome proliferator-activated receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    P37232
    UniProtKB/TrEMBL
    A0A974D847, Q6AXA9
    Related
    ENSXLAP00005000573.1, ENSXLAT00005000600.1
    Conserved Domains (2) summary
    cd06932
    Location:208 → 473
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37232.1 GenPept UniProtKB/Swiss-Prot:P37232

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