U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

arhgef12.S Rho guanine nucleotide exchange factor 12 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398710, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
arhgef12.S
Official Full Name
Rho guanine nucleotide exchange factor 12 S homeolog
Primary source
Xenbase:XB-GENE-865525
Locus tag
XELAEV_18037420mg
See related
EnsemblRapid:ENSXLAG00005021645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
larg; arhgef12
Annotation information
Annotation category: partial on reference assembly
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See arhgef12.S in Genome Data Viewer
Location:
chromosome: 7S
Exon count:
41
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (67931377..68026781)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (53606309..53702152)

Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene out at first homolog S homeolog Neighboring gene POU class 2 homeobox 3 S homeolog Neighboring gene glutamate receptor, ionotropic, kainate 4 S homeolog Neighboring gene tubulin folding cofactor E-like S homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. [Involvement of guanine nucleotide exchange factor xLARG in epiboly of cells of the animal pole of Xenopus laevis embryos]. Kiriukhin DO, et al. Biofizika, 2010 Nov-Dec. PMID 21268343
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. xLARG is involved in maintaining the xLARG activation level necessary for the occurrence of epiboly.
    Title: [Involvement of guanine nucleotide exchange factor xLARG in epiboly of cells of the animal pole of Xenopus laevis embryos].
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rho guanine nucleotide exchange factor 12 S homeolog
Names
Rho guanine nucleotide exchange factor (GEF) 12
guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089294.1 → NP_001082763.1  Rho guanine nucleotide exchange factor 12 S homeolog

    See identical proteins and their annotated locations for NP_001082763.1

    Status: PROVISIONAL

    Source sequence(s)
    AY211396
    UniProtKB/TrEMBL
    B7ZS88, Q6XS95
    Related
    ENSXLAP00005064303.1, ENSXLAT00005065817.1
    Conserved Domains (4) summary
    cd00992
    Location:73 → 147
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00621
    Location:775 → 960
    RhoGEF; RhoGEF domain
    cl02565
    Location:337 → 558
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl17171
    Location:979 → 1116
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    67931377..68026781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials