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CHRM2 cholinergic receptor muscarinic 2 [ Sus scrofa (pig) ]

Gene ID: 397498, updated on 17-Aug-2024

Summary

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Official Symbol
CHRM2provided by VGNC
Official Full Name
cholinergic receptor muscarinic 2provided by VGNC
Primary source
VGNC:VGNC:103922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in heart (RPKM 8.6), lung (RPKM 2.5) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CHRM2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (12455139..12600314, complement)

Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106506761 Neighboring gene uncharacterized LOC110257606 Neighboring gene pleiotrophin Neighboring gene uncharacterized LOC100621475 Neighboring gene microRNA mir-490-1 Neighboring gene uncharacterized LOC106506762 Neighboring gene uncharacterized LOC110257540

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_010460.4 Chromosome 18 Reference Sscrofa11.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers.
    Title: Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors.
  2. Expression and function of M2 and M3 receptors are similar in the detrusor of juvenile and mature pigs.
    Title: Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue.
  3. M2 and M3 receptors are upregulated in a time-dependent and pressure-dependent fashion after as little as a 24 h exposure to increased hydrostatic pressure in bladder
    Title: Muscarinic receptor expression increases following exposure to intravesical pressures of < or =40 cm-H2O: a possible mechanism for pressure-induced cell proliferation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
muscarinic acetylcholine receptor M2
Names
cardiac muscarinic acetylcholine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214261.1 → NP_999426.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_999426.1

    Status: PROVISIONAL

    Source sequence(s)
    X04708
    UniProtKB/Swiss-Prot
    P06199
    UniProtKB/TrEMBL
    A0A287BAI1
    Conserved Domains (2) summary
    pfam00001
    Location:40 → 222
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35 → 165
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

    Range
    12455139..12600314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021078515.1 → XP_020934174.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/TrEMBL
    A0A287BAI1, A0A8D1FPU0
    Conserved Domains (1) summary
    cd15297
    Location:24 → 451
    7tmA_mAChR_M2; muscarinic receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_021078513.1 → XP_020934172.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/TrEMBL
    A0A287BAI1, A0A8D1FPU0
    Conserved Domains (1) summary
    cd15297
    Location:24 → 451
    7tmA_mAChR_M2; muscarinic receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_021078516.1 → XP_020934175.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/TrEMBL
    A0A287BAI1, A0A8D1FPU0
    Conserved Domains (1) summary
    cd15297
    Location:24 → 451
    7tmA_mAChR_M2; muscarinic receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_021078514.1 → XP_020934173.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/TrEMBL
    A0A287BAI1, A0A8D1FPU0
    Conserved Domains (1) summary
    cd15297
    Location:24 → 451
    7tmA_mAChR_M2; muscarinic receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_021078517.1 → XP_020934176.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/TrEMBL
    A0A287BAI1, A0A8D1FPU0
    Conserved Domains (1) summary
    cd15297
    Location:24 → 451
    7tmA_mAChR_M2; muscarinic receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06199.1 GenPept UniProtKB/Swiss-Prot:P06199

Gene LinkOut

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