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THRA thyroid hormone receptor alpha [ Sus scrofa (pig) ]

Gene ID: 397387, updated on 17-Aug-2024

Summary

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Official Symbol
THRAprovided by VGNC
Official Full Name
thyroid hormone receptor alphaprovided by VGNC
Primary source
VGNC:VGNC:93963
See related
Ensembl:ENSSSCG00000035969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
NR1A1; C-ERBA-ALPHA
Expression
Ubiquitous expression in heart (RPKM 34.9), ovary (RPKM 33.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See THRA in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (22270506..22296684, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (22488984..22497735)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene CASC3 exon junction complex subunit Neighboring gene MSL complex subunit 1 Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene mediator complex subunit 24 Neighboring gene colony stimulating factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Mapping, expression and regulation of the TRα gene in porcine adipose tissue. Cai ZW, et al. Genet Mol Res, 2011 Jul 5. PMID 21751158
  2. Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development. White P, et al. J Mol Endocrinol, 1999 Oct. PMID 10514561
  3. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Zhang Y, et al. Blood, 2017 Nov 16. PMID 28972010
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the TR-KLF9 axis is responsible for the hematopoietic dysfunction in congenital hypothyroidism
    Title: Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
  2. there is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue.
    Title: Mapping, expression and regulation of the TRα gene in porcine adipose tissue.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thyroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyroid hormone receptor alpha
Names
c-erbA-1
nuclear receptor subfamily 1 group A member 1
thyroid hormone receptor alpha 2
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214190.1 → NP_999355.1  thyroid hormone receptor alpha

    See identical proteins and their annotated locations for NP_999355.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ005797
    UniProtKB/TrEMBL
    A0A480Q663, A0A8D1A594
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    22270506..22296684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021066243.1 → XP_020921902.1  thyroid hormone receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A480Q663, A0A8D1A594
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  2. XM_021066245.1 → XP_020921904.1  thyroid hormone receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A480Q663, A0A8D1A594
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  3. XM_021066244.1 → XP_020921903.1  thyroid hormone receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A480Q663, A0A8D1A594
    Related
    ENSSSCP00000036874.1, ENSSSCT00000047067.3
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97716.1 GenPept UniProtKB/Swiss-Prot:O97716

Gene LinkOut

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