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NR5A1 nuclear receptor subfamily 5 group A member 1 [ Sus scrofa (pig) ]

Gene ID: 397368, updated on 17-Aug-2024

Summary

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Official Symbol
NR5A1provided by VGNC
Official Full Name
nuclear receptor subfamily 5 group A member 1provided by VGNC
Primary source
VGNC:VGNC:90886
See related
Ensembl:ENSSSCG00000005588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
SF-1
Expression
Biased expression in ovary (RPKM 15.0) and spleen (RPKM 5.4) See more
Orthologs
human mouse all
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Genomic context

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See NR5A1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (265284491..265311547, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (299123683..299135326)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 7 Neighboring gene adhesion G protein-coupled receptor D2 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene uncharacterized LOC110256222 Neighboring gene microRNA mir-181a-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Genetic variation of the porcine NR5A1 is associated with meat color. Görres A, et al. J Appl Genet, 2016 Feb. PMID 26055431
  2. Porcine steroidogenic factor-1 gene (pSF-1) expression and analysis of embryonic pig gonads during sexual differentiation. Pilon N, et al. Endocrinology, 1998 Sep. PMID 9724033
  3. miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis. Liu J, et al. Biochim Biophys Acta Gene Regul Mech, 2018 Mar. PMID 29378329
  4. Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19. Lahbib-Mansais Y, et al. Cytogenet Cell Genet, 1997. PMID 9154138
  5. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. liver receptor homolog (LRH)-1, not CYP19A1, is a direct functional target of miR-1275.
    Title: miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis.
  2. NR5A1 variations influence meat color in a hypothalamus-pituitary-adrenal axis independent manner
    Title: Genetic variation of the porcine NR5A1 is associated with meat color.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
steroidogenic factor 1
Names
STF-1
adrenal 4-binding protein
fushi tarazu factor homolog 1
steroid hormone receptor Ad4BP
steroidogenic factor-1 SF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214179.1 → NP_999344.1  steroidogenic factor 1

    See identical proteins and their annotated locations for NP_999344.1

    Status: PROVISIONAL

    Source sequence(s)
    U84399
    UniProtKB/TrEMBL
    A0A8D1MPH9
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    265284491..265311547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021082954.1 → XP_020938613.1  steroidogenic factor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2BD07, P79387
    UniProtKB/TrEMBL
    A0A8D1MPH9
    Related
    ENSSSCP00000047808.1, ENSSSCT00000034748.3
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

  2. XM_021082957.1 → XP_020938616.1  steroidogenic factor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2BD07, P79387
    UniProtKB/TrEMBL
    A0A8D1MPH9
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79387.3 GenPept UniProtKB/Swiss-Prot:P79387

Gene LinkOut

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