F3 coagulation factor III, tissue factor [Sus scrofa (pig)] - Gene

Summary

Official Symbol: F3provided by VGNC
Official Full Name: coagulation factor III, tissue factorprovided by VGNC
Primary source: VGNC:VGNC:87864
See related: Ensembl:ENSSSCG00000022447
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in subcutaneous adipose (RPKM 68.9), lung (RPKM 37.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (122827018..122837673)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (134474466..134479707)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.
Title: The importance of tissue factor expression by porcine NICC in triggering IBMIR in the xenograft setting.
Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI, thus possibly modulating the risk of late thrombosis.
Title: Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
Title: Short-term myocardial ischemia induces cardiac modified C-reactive protein expression and proinflammatory gene (cyclo-oxygenase-2, monocyte chemoattractant protein-1, and tissue factor) upregulation in peripheral blood mononuclear cells.
Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.
Title: Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tissue factor

Names: coagulation factor III (thromboplastin, tissue factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213785.1 → NP_998950.1 tissue factor

See identical proteins and their annotated locations for NP_998950.1

Status: PROVISIONAL

Source sequence(s)

AY504424

UniProtKB/TrEMBL

A0A4X1TT00, I3LE68, Q6RCS8

Related

ENSSSCP00000022354.2, ENSSSCT00000027504.4

Conserved Domains (2) summary

pfam01108
Location:34 → 114

Tissue_fac; Tissue factor

pfam09294
Location:135 → 242

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010446.5 Reference Sscrofa11.1 Primary Assembly

Range

122827018..122837673

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021088682.1 → XP_020944341.1 tissue factor isoform X1

Conserved Domains (2) summary

pfam01108
Location:34 → 114

Tissue_fac; Tissue factor

cl21522
Location:135 → 194

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...