BAX BCL2 associated X, apoptosis regulator [Sus scrofa (pig)] - Gene

Summary

Gene symbol: BAX
Gene description: BCL2 associated X, apoptosis regulator
See related: Ensembl:ENSSSCG00000061946
Gene type: protein coding
RefSeq status: MODEL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: BAX-ALPHA
Expression: Ubiquitous expression in spleen (RPKM 23.8), ovary (RPKM 20.6) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (54222341..54228150)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (50100514..50106337, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
Title: Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
Bid and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
Title: Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries.
The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
Title: Effects of severe hypocapnia on expression of bax and bcl-2 proteins, DNA fragmentation, and membrane peroxidation products in cerebral cortical mitochondria of newborn piglets.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH47233 (e-PCR)
- UniSTS:35847

GDB:632822 (e-PCR)
- UniSTS:158495

PMC230316P5 (e-PCR)
- UniSTS:272183

BAX (e-PCR)
- UniSTS:498075

PMC114802P1 (e-PCR)
- UniSTS:270279

PMC27116P1 (e-PCR)
- UniSTS:272373

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitochondrial fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: apoptosis regulator BAX

Names: BCL2-associated X protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010448.4 Reference Sscrofa11.1 Primary Assembly

Range

54222341..54228150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003127290.5 → XP_003127338.2 apoptosis regulator BAX isoform X1

UniProtKB/TrEMBL

A0A286ZTT0, A0A4X1W035, A0A4X1W1A2

Related

ENSSSCP00000034895.2, ENSSSCT00000063771.2

Conserved Domains (2) summary

cd06845
Location:25 → 164

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:5 → 192

bcl-2; apoptosis regulator
XM_013998624.2 → XP_013854078.1 apoptosis regulator BAX isoform X2

UniProtKB/TrEMBL

Q70AD3

Conserved Domains (2) summary

cd06845
Location:5 → 127

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 155

bcl-2; apoptosis regulator