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LGALS3BP galectin 3 binding protein [ Homo sapiens (human) ]

Gene ID: 3959, updated on 2-Nov-2024

Summary

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Official Symbol
LGALS3BPprovided by HGNC
Official Full Name
galectin 3 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:6564
See related
Ensembl:ENSG00000108679 MIM:600626; AllianceGenome:HGNC:6564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues See more
Orthologs
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Genomic context

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See LGALS3BP in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78971255..78979923, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79866027..79877550, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76967337..76976005, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76869765-76870265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76874955-76875848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76875849-76876740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76877535-76878035 Neighboring gene Sharpr-MPRA regulatory region 5911/8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9076 Neighboring gene CEP295 N-terminal like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76898462-76899062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76911943-76912638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76912639-76913334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76914785-76915760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12914 Neighboring gene Sharpr-MPRA regulatory region 14803 Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76972258-76972941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76976039-76977031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1q and TNF related 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Galectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus. Peretz ASR, et al. Clin Exp Rheumatol, 2021 Nov-Dec. PMID 33337998
  2. Hepatic stellate cells secreting WFA(+) -M2BP: Its role in biological interactions with Kupffer cells. Bekki Y, et al. J Gastroenterol Hepatol, 2017 Jul. PMID 28008658
  3. Serum Mac-2-binding protein glycosylation isomer predicts esophagogastric varices in cirrhotic patients with chronic hepatitis C virus infection treated with IFN-free direct-acting antiviral agent: M2BPGi levels predict varices in SVR patients. Kikukawa K, et al. Ann Hepatol, 2020 Jul-Aug. PMID 32444247
  4. Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein but not α-fetoprotein as a Long-Term Hepatocellular Carcinoma Predictor. Osawa L, et al. Int J Mol Sci, 2020 May 21. PMID 32455631, Free PMC Article
  5. Clinical significance of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in pancreatic ductal adenocarcinoma. Waragai Y, et al. Pancreatology, 2016 Nov-Dec. PMID 27665173

See all (253) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrant expression of LGALS3BP drives an unfavorable prognosis and more aggressive in HCC via regulating PI3K/AKT signaling.
    Title: Aberrant expression of LGALS3BP drives an unfavorable prognosis and more aggressive in HCC via regulating PI3K/AKT signaling.
  2. Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
    Title: Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
  3. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer.
    Title: Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer.
  4. Diagnostic Value of Serum Galectin-3 Binding Protein Level in Patients with Pulmonary Arterial Hypertension.
    Title: Diagnostic Value of Serum Galectin-3 Binding Protein Level in Patients with Pulmonary Arterial Hypertension.
  5. LGALS3BP is a novel and potential biomarker in clear cell renal cell carcinoma.
    Title: LGALS3BP is a novel and potential biomarker in clear cell renal cell carcinoma.
  6. 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
    Title: 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
  7. Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
    Title: Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
  8. Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis.
    Title: Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-κB axis.
  9. Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
    Title: Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
  10. Platelet LGALS3BP as a Mediator of Myeloid Inflammation in Systemic Lupus Erythematosus.
    Title: Platelet LGALS3BP as a Mediator of Myeloid Inflammation in Systemic Lupus Erythematosus.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 replication is inhibited by LGALS3BP (M2BP) overexpression in 293HEK cells PubMed
Knockdown of 90K/LGALS3BP by siRNA enhances replication and infectivity of HIV-1 in TZM-bl cells and primary macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Envelope surface glycoprotein gp160, precursor env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Envelope transmembrane glycoprotein gp41 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag HIV-1 Gag trafficking to the plasma membrane is inhibited by LGALS3BP (M2BP) and the inhibition by LGALS3BP is dependent upon vimentin PubMed
gag HIV-1 Gag binds to LGALS3BP (M2BP) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in platelet dense granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
galectin-3-binding protein
Names
L3 antigen
MAC2BP
Mac-2-binding protein
basement membrane autoantigen p105
lectin galactoside-binding soluble 3-binding protein
mac-2 BP
serum protein 90K
transport and golgi organization 10 homolog B
tumor-associated antigen 90K
NP_005558.1
XP_054172018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005567.4 → NP_005558.1  galectin-3-binding protein precursor

    See identical proteins and their annotated locations for NP_005558.1

    Status: REVIEWED

    Source sequence(s)
    BC002403, L13210
    Consensus CDS
    CCDS11759.1
    UniProtKB/Swiss-Prot
    A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
    UniProtKB/TrEMBL
    B4DVE1
    Related
    ENSP00000262776.2, ENST00000262776.8
    Conserved Domains (3) summary
    smart00202
    Location:24 → 124
    SR; Scavenger receptor Cys-rich
    cd18304
    Location:136 → 247
    BTB_POZ_M2BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP)
    cd18496
    Location:256 → 329
    BACK_LGALS3BP; BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78971255..78979923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79866027..79877550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316043.1 → XP_054172018.1  galectin-3-binding protein isoform X1

    UniProtKB/Swiss-Prot
    A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08380.1 GenPept UniProtKB/Swiss-Prot:Q08380

Gene LinkOut

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