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Spt20 Spt20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39522, updated on 2-Nov-2024

Summary

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Official Symbol
Spt20provided by FlyBase
Official Full Name
Spt20provided by FlyBase
Primary source
FLYBASE:FBgn0036374
Locus tag
Dmel_CG17689
See related
AllianceGenome:FB:FBgn0036374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17689; Dmel\CG17689; dSpt20; lincRNA.S5070
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in chromatin organization and regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in chordotonal neurons. Orthologous to several human genes including SUPT20H (SPT20 homolog, SAGA complex component). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Spt20 in Genome Data Viewer
Location:
70B3-70B4; 3-40 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13502707..13511541)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13495807..13504641)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Actin binding protein 1 Neighboring gene Tondu-domain-containing Growth Inhibitor Neighboring gene Liprin-beta Neighboring gene Vacuolar protein sorting 36 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
  2. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Mohan RD, et al. Genes Dev, 2014 Feb 1. PMID 24493646, Free PMC Article
  3. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556
  4. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111
  5. The gang of four gene regulates growth and patterning of the developing Drosophila eye. Beam CK, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473027, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SAGA-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Spt20
Names
CG17689-PA
CG17689-PC
CG17689-PD
Spt20-PA
Spt20-PC
Spt20-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13502707..13511541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140402.5 → NP_648659.2  Spt20, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648659.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U0Z4, Q9VU86
    Conserved Domains (1) summary
    pfam12090
    Location:429 → 559
    Spt20; Spt20 family

  2. NM_001038916.3 → NP_001034005.2  Spt20, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034005.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PDX8
    Conserved Domains (1) summary
    pfam12090
    Location:429 → 559
    Spt20; Spt20 family

  3. NM_001300133.1 → NP_001287062.1  Spt20, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U0Z4, Q9VU86
    Conserved Domains (1) summary
    pfam12090
    Location:429 → 559
    Spt20; Spt20 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PDX8 Q2PDX8
Q9VU86 Q9VU86

Gene LinkOut

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