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Cyp2d12 cytochrome P450, family 2, subfamily d, polypeptide 12 [ Mus musculus (house mouse) ]

Gene ID: 380997, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp2d12provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 12provided by MGI
Primary source
MGI:MGI:88604
See related
Ensembl:ENSMUSG00000096852 AllianceGenome:MGI:88604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030605E09Rik
Summary
Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 25.1), kidney adult (RPKM 22.9) and 2 other tissues See more
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Genomic context

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See Cyp2d12 in Genome Data Viewer
Location:
15 E1; 15 38.64 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82439244..82443614)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82555043..82559413)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46524 Neighboring gene STARR-seq mESC enhancer starr_39297 Neighboring gene predicted gene, 28023 Neighboring gene STARR-seq mESC enhancer starr_39298 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 33, pseudogene Neighboring gene STARR-seq mESC enhancer starr_39299 Neighboring gene STARR-seq mESC enhancer starr_39300 Neighboring gene STARR-seq mESC enhancer starr_39301 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 34, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Nelson DR, et al. DNA Cell Biol, 1993 Jan-Feb. PMID 7678494
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anandamide 11,12 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 14,15 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 8,9 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily d, polypeptide 12
Names
cytochrome P450, 2d12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355665.1 → NP_001342594.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132878
    Consensus CDS
    CCDS88815.1
    UniProtKB/TrEMBL
    B7ZP10, D3Z6U9
    Related
    ENSMUSP00000154856.2, ENSMUST00000229904.2
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 445
    p450; Cytochrome P450

  2. NM_201360.2 → NP_958748.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 1

    See identical proteins and their annotated locations for NP_958748.1

    Status: VALIDATED

    Source sequence(s)
    AC132878
    Consensus CDS
    CCDS37160.1
    UniProtKB/TrEMBL
    Q8BVD2
    Related
    ENSMUSP00000071064.7, ENSMUST00000068861.8
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82439244..82443614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521128.3 → XP_006521191.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X1

    See identical proteins and their annotated locations for XP_006521191.1

    Conserved Domains (1) summary
    pfam00067
    Location:12 → 471
    p450; Cytochrome P450

  2. XM_006521132.2 → XP_006521195.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X3

    See identical proteins and their annotated locations for XP_006521195.1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 421
    p450; Cytochrome P450

  3. XM_006521130.1 → XP_006521193.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:37 → 437
    p450; Cytochrome P450

  4. XM_006521131.1 → XP_006521194.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X3

    See identical proteins and their annotated locations for XP_006521194.1

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 421
    p450; Cytochrome P450

RNA

  1. XR_875302.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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