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pgr.L progesterone receptor L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373633, updated on 18-Sep-2024

Summary

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Official Symbol
pgr.L
Official Full Name
progesterone receptor L homeolog
Primary source
Xenbase:XB-GENE-865085
Locus tag
XELAEV_18013842mg
See related
EnsemblRapid:ENSXLAG00005000641
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pgr; ipgr; XPR-1; pgr-a; pgr-b; xpr-2
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Genomic context

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See pgr.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (172398718..172446783)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (165073009..165120823)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene centromere protein J L homeolog Neighboring gene transient receptor potential cation channel, subfamily C, member 6 L homeolog Neighboring gene small nuclear ribonucleoprotein-associated protein B'-like Neighboring gene Rho GTPase activating protein 42 L homeolog Neighboring gene 5.8S ribosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand-binding domain. Martinez S, et al. J Cell Physiol, 2007 May. PMID 17219407
  2. Plasma membrane destination of the classical Xenopus laevis progesterone receptor accelerates progesterone-induced oocyte maturation. Martinez S, et al. J Cell Biochem, 2006 Oct 15. PMID 16721828
  3. Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation. Tian J, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11114187, Free PMC Article
  4. Transcription-dependent and transcription-independent functions of the classical progesterone receptor in Xenopus ovaries. Liu XS, et al. Dev Biol, 2005 Jul 1. PMID 15890333
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the classical xPR-1, located at the plasma membrane, mediates reinitiation of the meiotic cell cycle in the X. laevis oocyte through a non-genomic mechanism.
    Title: Plasma membrane destination of the classical Xenopus laevis progesterone receptor accelerates progesterone-induced oocyte maturation.
  2. results suggest that the dual functions of progesterone, transcription-dependent follicle rupture and transcription-independent oocyte maturation, are mediated by the two forms of PR proteins differentially expressed in the follicle cells and the oocytes
    Title: Transcription-dependent and transcription-independent functions of the classical progesterone receptor in Xenopus ovaries.
  3. Xenopus laevis progesterone receptor is capable of associating with the plasma membrane and this association is through its ligang-binding domain.
    Title: Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand-binding domain.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
progesterone receptor L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085631.1 → NP_001079100.1  progesterone receptor L homeolog

    See identical proteins and their annotated locations for NP_001079100.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068635
    UniProtKB/TrEMBL
    A0A974DQB3, Q9DDU9
    Conserved Domains (2) summary
    cd07074
    Location:485 → 732
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:361 → 438
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    172398718..172446783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041580821.1 → XP_041436755.1  progesterone receptor L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1M6S8
    Related
    ENSXLAP00005001843.1, ENSXLAT00005001884.1
    Conserved Domains (2) summary
    cd07074
    Location:484 → 731
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:360 → 437
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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