Smad6 SMAD family member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smad6provided by RGD
Official Full Name: SMAD family member 6provided by RGD
Primary source: RGD:1305069
See related: EnsemblRapid:ENSRNOG00000009173 AllianceGenome:RGD:1305069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including SMAD binding activity; protein sequestering activity; and signaling receptor binding activity. Involved in response to estrogen. Predicted to be located in Golgi apparatus; cytosol; and nuclear body. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in cytoplasm. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis 7; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 412.7), Heart (RPKM 71.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (73345457..73414985, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (64450114..64519673, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (68897746..68967221, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-20a-5p regulated SMAD6 to inhibit chondrogenesis of hDPSCs.
Title: miR-20a-5p regulated SMAD6 to inhibit chondrogenesis of hDPSCs.
MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats.
Title: MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats.
MiR-134 directly targetted the 3'-UTRs of SMAD6 in the bone marrow mesenchymal stem cells.
Title: miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6.
Suggest role for Smad6 signaling in cerebral ischemia.
Title: The effects of Smad6 via small RNA pathways on the ischemic injury in PC12 cells.
These results suggest that Smad6 is a regulatory molecule which regulates the proliferation, self-renewal and Wnt/beta-catenin signaling in HPCs.
Title: Smad6 suppresses the growth and self-renewal of hepatic progenitor cells.
stretch decreased Smad6 mRNA
Title: Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells.
In the early stage of diabetic nephropathy, increase in BMP-7 and Smad6/7 expression may play a role in the feedback regulation and restrain the development of diabetic nephropathy.
Title: [Changes of bone morphogenetic protein-7 and inhibitory Smad expression in streptozotocin-induced diabetic nephropathy rat kidney].
Smad6 most potently functions to block dI1 axon outgrowth.
Title: Inhibitory Smads differentially regulate cell fate specification and axon dynamics in the dorsal spinal cord.
JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor.
Title: Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor.

Submit: New GeneRIF Correction

General gene information

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Markers

Smad6 (e-PCR), detects polymorphism
- UniSTS:516411

RH130848 (e-PCR)
- UniSTS:214132

Smad5 (e-PCR), detects polymorphism
- UniSTS:466573

AU046917 (e-PCR)
- UniSTS:111017

AU046916 (e-PCR)
- UniSTS:115919

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables type I activin receptor binding	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart valve development	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to laminar fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in zygotic specification of dorsal/ventral axis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mothers against decapentaplegic homolog 6

Names: MAD homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109002.3 → NP_001102472.2 mothers against decapentaplegic homolog 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J5A7, D3ZAQ2

Related

ENSRNOP00000012155.8, ENSRNOT00000012155.9

Conserved Domains (2) summary

cd10493
Location:161 → 274

MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6

cd10499
Location:323 → 493

MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

73345457..73414985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243242.5 → XP_006243304.1 mothers against decapentaplegic homolog 6 isoform X1

See identical proteins and their annotated locations for XP_006243304.1

UniProtKB/TrEMBL

A6J5A7, D3ZAQ2

Conserved Domains (2) summary

cd10493
Location:161 → 274

MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6

cd10499
Location:323 → 493

MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6