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Neil1 nei-like DNA glycosylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367090, updated on 10-Oct-2024

Summary

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Official Symbol
Neil1provided by RGD
Official Full Name
nei-like DNA glycosylase 1provided by RGD
Primary source
RGD:1306077
See related
EnsemblRapid:ENSRNOG00000018577 AllianceGenome:RGD:1306077
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable catalytic activity, acting on DNA; lyase activity; and protein C-terminus binding activity. Predicted to be involved in base-excision repair; negative regulation of nuclease activity; and response to oxidative stress. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 93.2), Kidney (RPKM 48.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Neil1 in Genome Data Viewer
Location:
8q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66446106..66452844, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57550142..57556884, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61817258..61824023, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene COMM domain containing 4 Neighboring gene voltage-dependent anion channel 2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity. Ma H, et al. Toxicol Appl Pharmacol, 2011 Feb 15. PMID 21145906, Free PMC Article
  2. The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. Das A, et al. J Biol Chem, 2007 Sep 7. PMID 17611195
  3. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. Takao M, et al. J Biol Chem, 2002 Nov 1. PMID 12200441
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the spleen aniline-induced oxidative stress is associated with an induction of NEIL1/2.
    Title: Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC116267

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclease activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endonuclease 8-like 1
Names
endonuclease VIII-like 1
nei endonuclease VIII-like 1
NP_001020925.1
XP_038937801.1
XP_038937802.1
XP_063121951.1
XP_063121952.1
XP_063121953.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025754.1 → NP_001020925.1  endonuclease 8-like 1

    See identical proteins and their annotated locations for NP_001020925.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099125
    UniProtKB/TrEMBL
    A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
    Related
    ENSRNOP00000055440.3, ENSRNOT00000058645.3
    Conserved Domains (3) summary
    PRK10445
    Location:134 → 194
    PRK10445; endonuclease VIII; Provisional
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66446106..66452844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265883.1 → XP_063121953.1  endonuclease 8-like 1 isoform X1

  2. XM_063265881.1 → XP_063121951.1  endonuclease 8-like 1 isoform X1

  3. XM_063265882.1 → XP_063121952.1  endonuclease 8-like 1 isoform X1

    Related
    ENSRNOP00000097715.2, ENSRNOT00000098070.2

  4. XM_039081874.2 → XP_038937802.1  endonuclease 8-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
    Conserved Domains (3) summary
    PRK10445
    Location:134 → 194
    PRK10445; endonuclease VIII; Provisional
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

  5. XM_039081873.2 → XP_038937801.1  endonuclease 8-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
    Related
    ENSRNOP00000077950.1, ENSRNOT00000095093.2
    Conserved Domains (3) summary
    PRK10445
    Location:134 → 194
    PRK10445; endonuclease VIII; Provisional
    pfam09292
    Location:252 → 290
    Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
    cl03119
    Location:1 → 127
    FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

RNA

  1. XR_005487880.2 RNA Sequence

  2. XR_010054008.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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