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Cdc26 cell division cycle 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366381, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc26provided by RGD
Official Full Name
cell division cycle 26provided by RGD
Primary source
RGD:1311342
See related
EnsemblRapid:ENSRNOG00000090496 AllianceGenome:RGD:1311342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BWK-2
Summary
Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC26 (cell division cycle 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 100.4), Brain (RPKM 87.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc26 in Genome Data Viewer
Location:
5q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80861658..80875326, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75844852..75859830, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78252168..78267137, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene solute carrier family 31 member 1 Neighboring gene pre-mRNA splicing tri-snRNP complex factor 4 Neighboring gene ring finger protein 183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit CDC26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013240.2 → NP_001013258.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_001013258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC086343, FM103539
    UniProtKB/Swiss-Prot
    Q6YDN7
    Related
    ENSRNOP00000106547.1, ENSRNOT00000141508.1
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 64
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  2. NM_001267054.1 → NP_001253983.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_001253983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q6YDN7
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 64
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  3. NM_001267055.1 → NP_001253984.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_001253984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC086343, DY317988, FM103539
    UniProtKB/Swiss-Prot
    Q6YDN7
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 64
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  4. NM_001395703.1 → NP_001382632.1  anaphase-promoting complex subunit CDC26

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q6YDN7
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 64
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  5. NM_001395704.1 → NP_001382633.1  anaphase-promoting complex subunit CDC26

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q6YDN7
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 64
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    80861658..80875326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288109.1 → XP_063144179.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q6YDN7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6YDN7.1 GenPept UniProtKB/Swiss-Prot:Q6YDN7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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