IRF3 interferon regulatory factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IRF3provided by HGNC
Official Full Name: interferon regulatory factor 3provided by HGNC
Primary source: HGNC:HGNC:6118
See related: Ensembl:ENSG00000126456 MIM:603734; AllianceGenome:HGNC:6118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IIAE7
Summary: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in spleen (RPKM 23.8), lymph node (RPKM 21.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49659572..49665857, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52659601..52665933, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (50162829..50169114, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense.
Title: Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense.
Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD.
Title: Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD.
Mammalian reovirus micro1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Title: Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
Title: Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.
IRF3 function and immunological gaps in sepsis.
Title: IRF3 function and immunological gaps in sepsis.
Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.
Title: Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.
The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3.
Title: The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3.
Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.
Title: Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.
Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.
Title: Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta Expression through Regulating IRF-3.
Title: FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.

Submit: New GeneRIF Correction See all GeneRIFs (312)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7 MedGen: C4225294 OMIM: 616532 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation	PubMed
Nef	nef	HIV-1 Nef myristoylation is required for the activation of IRF-3, leading to the synthesis of IFNbeta in monocytes-derived-macrophages	PubMed
	nef	The acidic cluster (residues 64-69) of HIV-1 Nef is required for IRF-3 activation and IFNbeta production	PubMed
Tat	tat	HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells	PubMed
Vif	vif	HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu	PubMed
	vif	Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation	PubMed
Vpr	vpr	HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu	PubMed
	vpr	HIV-1 Vpr-mediated suppression of IFN induction is caused by failure of IRF-3 nucleus translocation	PubMed
	vpr	Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation	PubMed
Vpu	vpu	HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu	PubMed
	vpu	Residue Asp121 is the primary site for Vpu-induced, caspase-mediated IRF3 cleavage, and the alternative site is residues Asp125 when Asp121 is mutated	PubMed
	vpu	Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage	PubMed
	vpu	HIV-1 Vpu-induced cleavage of IRF3 is largely dependent on the ability of Vpu to interact with beta-TrCP, and mutation of the Vpu phosphorylation sites Ser52 and Ser56 greatly decreases the function of Vpu-induced IRF3 cleavage	PubMed
	vpu	HIV-1 Vpu co-localizes with IRF3 during HIV protein expression	PubMed
	vpu	Interaction of HIV-1 Vpu with IRF3 governs the innate immune response of the host cell to HIV-1 infection	PubMed
	vpu	HIV-1 Vpu forms a stable and specific complex with IRF3 in HIV-1-infected cells, resulting in its specific sequestration within the endo-lysosomal compartment	PubMed
capsid	gag	HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state	PubMed
reverse transcriptase	gag-pol	The reverse-transcribed viral DNA by HIV-1 RT is the trigger of IRF3 activation and IFN-beta production in HIV-1 infected human monocytic cell line THP1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62110 (e-PCR)
- UniSTS:139152

SGC34742 (e-PCR)
- UniSTS:76981

NIB1805 (e-PCR)
- UniSTS:12987

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IC Inferred by Curator more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	TAS Traceable Author Statement more info	PubMed
involved_in MDA-5 signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in TRIF-dependent toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cGAS/STING signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interferon-alpha production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in programmed necrotic cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction involved in regulation of gene expression	TAS Traceable Author Statement more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031810.1 RefSeqGene

Range

5019..11304

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001197122.2 → NP_001184051.1 interferon regulatory factor 3 isoform 2

See identical proteins and their annotated locations for NP_001184051.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.

Source sequence(s)

BC000660, DA999381

Consensus CDS

CCDS59409.1

UniProtKB/TrEMBL

M0QZB7

Related

ENSP00000471896.1, ENST00000601291.5

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 326

IRF-3; Interferon-regulatory factor 3
NM_001197123.2 → NP_001184052.1 interferon regulatory factor 3 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as IRF3a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

BC000660, BP347627, BU859806, DA999381, HM357932, HM357934

UniProtKB/TrEMBL

E2GIM5

Conserved Domains (2) summary

pfam10401
Location:167 → 345

IRF-3; Interferon-regulatory factor 3

cl00096
Location:21 → 75

IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
NM_001197124.2 → NP_001184053.1 interferon regulatory factor 3 isoform 4

See identical proteins and their annotated locations for NP_001184053.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as IRF3e and IRF3-nirs3) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

BC000660, BU859806, DA999381, HM357935, HM357936

Consensus CDS

CCDS56099.1

UniProtKB/TrEMBL

E2GIM9

Related

ENSP00000471358.1, ENST00000599223.5

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:200 → 253

IRF-3; Interferon-regulatory factor 3
NM_001197125.2 → NP_001184054.1 interferon regulatory factor 3 isoform 5

See identical proteins and their annotated locations for NP_001184054.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as IRF3f) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).

Source sequence(s)

BC000660, BU859806, DA999381, HM357937

Consensus CDS

CCDS59408.1

UniProtKB/TrEMBL

M0QYT9

Related

ENSP00000366339.5, ENST00000377135.8

Conserved Domains (1) summary

pfam10401
Location:56 → 234

IRF-3; Interferon-regulatory factor 3
NM_001197126.2 → NP_001184055.1 interferon regulatory factor 3 isoform 5

See identical proteins and their annotated locations for NP_001184055.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as IRF3c) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).

Source sequence(s)

BC000660, BU859806, DA999381, HM357934

Consensus CDS

CCDS59408.1

UniProtKB/TrEMBL

M0QYT9

Related

ENSP00000470069.1, ENST00000599144.5

Conserved Domains (1) summary

pfam10401
Location:56 → 234

IRF-3; Interferon-regulatory factor 3
NM_001197127.2 → NP_001184056.1 interferon regulatory factor 3 isoform 6

See identical proteins and their annotated locations for NP_001184056.1

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as IRF3d) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).

Source sequence(s)

BC000660, BU859806, DA999381, HM357935

Consensus CDS

CCDS59407.1

UniProtKB/TrEMBL

E2GIM8

Related

ENSP00000472700.1, ENST00000600022.5

Conserved Domains (1) summary

pfam10401
Location:54 → 107

IRF-3; Interferon-regulatory factor 3
NM_001197128.2 → NP_001184057.1 interferon regulatory factor 3 isoform 6

See identical proteins and their annotated locations for NP_001184057.1

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as IRF3b) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).

Source sequence(s)

BC000660, BU859806, DA999381, HM357933, HM357935

Consensus CDS

CCDS59407.1

UniProtKB/TrEMBL

E2GIM8

Related

ENSP00000470512.1, ENST00000596765.5

Conserved Domains (1) summary

pfam10401
Location:54 → 107

IRF-3; Interferon-regulatory factor 3
NM_001571.6 → NP_001562.1 interferon regulatory factor 3 isoform 1

See identical proteins and their annotated locations for NP_001562.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC011495, DA999381, Z56281

Consensus CDS

CCDS12775.1

UniProtKB/Swiss-Prot

A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6

UniProtKB/TrEMBL

E2GIM5

Related

ENSP00000366344.3, ENST00000377139.8

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 380

IRF-3; Interferon-regulatory factor 3

RNA

NR_045568.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA568913, AK292027, DA938709

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

49659572..49665857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438784.1 → XP_047294740.1 interferon regulatory factor 3 isoform X6
XM_017026767.2 → XP_016882256.1 interferon regulatory factor 3 isoform X2

UniProtKB/Swiss-Prot

A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6

UniProtKB/TrEMBL

E2GIM5

Related

ENSP00000310127.6, ENST00000309877.11

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 380

IRF-3; Interferon-regulatory factor 3
XM_006723198.2 → XP_006723261.1 interferon regulatory factor 3 isoform X1

See identical proteins and their annotated locations for XP_006723261.1

UniProtKB/TrEMBL

M0QZB7

Related

ENSP00000470431.1, ENST00000600911.5

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 326

IRF-3; Interferon-regulatory factor 3
XM_024451495.2 → XP_024307263.1 interferon regulatory factor 3 isoform X6

Conserved Domains (1) summary

pfam10401
Location:56 → 180

IRF-3; Interferon-regulatory factor 3
XM_017026766.2 → XP_016882255.1 interferon regulatory factor 3 isoform X2

UniProtKB/Swiss-Prot

A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6

UniProtKB/TrEMBL

E2GIM5

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 380

IRF-3; Interferon-regulatory factor 3
XM_006723197.1 → XP_006723260.1 interferon regulatory factor 3 isoform X1

See identical proteins and their annotated locations for XP_006723260.1

UniProtKB/TrEMBL

M0QZB7

Conserved Domains (2) summary

pfam00605
Location:7 → 110

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:202 → 326

IRF-3; Interferon-regulatory factor 3
XM_006723201.2 → XP_006723264.1 interferon regulatory factor 3 isoform X6

See identical proteins and their annotated locations for XP_006723264.1

Conserved Domains (1) summary

pfam10401
Location:56 → 180

IRF-3; Interferon-regulatory factor 3
XM_047438785.1 → XP_047294741.1 interferon regulatory factor 3 isoform X7

UniProtKB/TrEMBL

M0QYT9

Related

ENSP00000472582.1, ENST00000598808.5
XM_024451494.2 → XP_024307262.1 interferon regulatory factor 3 isoform X6

Conserved Domains (1) summary

pfam10401
Location:56 → 180

IRF-3; Interferon-regulatory factor 3
XM_006723200.2 → XP_006723263.1 interferon regulatory factor 3 isoform X3

UniProtKB/TrEMBL

M0QZB7

Conserved Domains (2) summary

pfam10401
Location:167 → 291

IRF-3; Interferon-regulatory factor 3

cl00096
Location:21 → 75

IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
XM_047438783.1 → XP_047294739.1 interferon regulatory factor 3 isoform X5
XM_047438782.1 → XP_047294738.1 interferon regulatory factor 3 isoform X4

RNA

XR_007066794.1 RNA Sequence
XR_007066795.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

52659601..52665933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320902.1 → XP_054176877.1 interferon regulatory factor 3 isoform X2
XM_054320900.1 → XP_054176875.1 interferon regulatory factor 3 isoform X1

UniProtKB/TrEMBL

Q96GL3
XM_054320908.1 → XP_054176883.1 interferon regulatory factor 3 isoform X6
XM_054320909.1 → XP_054176884.1 interferon regulatory factor 3 isoform X7

UniProtKB/TrEMBL

E2GIM7
XM_054320907.1 → XP_054176882.1 interferon regulatory factor 3 isoform X6
XM_054320901.1 → XP_054176876.1 interferon regulatory factor 3 isoform X1

UniProtKB/TrEMBL

Q96GL3
XM_054320903.1 → XP_054176878.1 interferon regulatory factor 3 isoform X3
XM_054320905.1 → XP_054176880.1 interferon regulatory factor 3 isoform X5
XM_054320904.1 → XP_054176879.1 interferon regulatory factor 3 isoform X4
XM_054320906.1 → XP_054176881.1 interferon regulatory factor 3 isoform X8