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Rnf144b ring finger protein 144B [ Rattus norvegicus (Norway rat) ]

Gene ID: 364681, updated on 2-Nov-2024

Summary

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Symbol
Rnf144bprovided by RGD
Full Name
ring finger protein 144Bprovided by RGD
Primary source
RGD:1308856
See related
EnsemblRapid:ENSRNOG00000016123 AllianceGenome:RGD:1308856
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ibrdc2
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Orthologous to human RNF144B (ring finger protein 144B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 94.9), Spleen (RPKM 56.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf144b in Genome Data Viewer
Location:
17p14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17637564..17786685, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17431271..17580687, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (17817122..17947777, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097957 Neighboring gene uncharacterized LOC120097909 Neighboring gene small nucleolar RNA U13 Neighboring gene DEK proto-oncogene Neighboring gene lysine demethylase 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. Benard G, et al. EMBO J, 2010 Apr 21. PMID 20300062, Free PMC Article
  2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Ng CC, et al. Oncogene, 2003 Jul 10. PMID 12853982
  3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF144B
Names
IBR domain containing 2
NP_001102351.1
XP_006253829.1
XP_038951898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108881.2 → NP_001102351.1  E3 ubiquitin-protein ligase RNF144B

    See identical proteins and their annotated locations for NP_001102351.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J6Z9, D3ZFK0
    Related
    ENSRNOP00000036422.4, ENSRNOT00000036876.6
    Conserved Domains (3) summary
    smart00647
    Location:101 → 166
    IBR; In Between Ring fingers
    cd16778
    Location:28 → 84
    mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
    pfam01485
    Location:183 → 223
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    17637564..17786685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095970.2 → XP_038951898.1  E3 ubiquitin-protein ligase RNF144B isoform X1

    UniProtKB/TrEMBL
    A6J6Z9, D3ZFK0
    Conserved Domains (3) summary
    smart00647
    Location:101 → 166
    IBR; In Between Ring fingers
    cd16778
    Location:28 → 84
    mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
    pfam01485
    Location:183 → 223
    IBR; IBR domain, a half RING-finger domain

  2. XM_006253767.5 → XP_006253829.1  E3 ubiquitin-protein ligase RNF144B isoform X1

    See identical proteins and their annotated locations for XP_006253829.1

    UniProtKB/TrEMBL
    A6J6Z9, D3ZFK0
    Conserved Domains (3) summary
    smart00647
    Location:101 → 166
    IBR; In Between Ring fingers
    cd16778
    Location:28 → 84
    mRING-HC-C4C4_RBR_RNF144B; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144B (RNF144B)
    pfam01485
    Location:183 → 223
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein Strain
Heading Accession and Version

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