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Nmnat3 nicotinamide nucleotide adenylyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363118, updated on 10-Jul-2024

Summary

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Official Symbol
Nmnat3provided by RGD
Official Full Name
nicotinamide nucleotide adenylyltransferase 3provided by RGD
Primary source
RGD:1309140
See related
EnsemblRapid:ENSRNOG00000013585 AllianceGenome:RGD:1309140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. Involved in response to tumor necrosis factor. Located in axon and neuronal cell body. Used to study glaucoma. Orthologous to human NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 86.9), Spleen (RPKM 81.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nmnat3 in Genome Data Viewer
Location:
8q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107771124..107888528)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (98892168..99003912)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106317038..106429535)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene calsyntenin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene retinol binding protein 1 Neighboring gene retinol binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration. Kitaoka Y, et al. Cell Death Dis, 2013 Oct 17. PMID 24136224, Free PMC Article
  2. NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy. Yue Z, et al. Exp Cell Res, 2016 Oct 1. PMID 27423420
  3. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. Sasaki Y, et al. J Neurosci, 2006 Aug 16. PMID 16914673, Free PMC Article
  4. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. Berger F, et al. J Biol Chem, 2005 Oct 28. PMID 16118205
  5. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, et al. Endocr Rev, 2010 Apr. PMID 20007326, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD.
    Title: NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
  2. These results suggest that the axonal-protective effect of Nmnat3 may be involved in autophagy machinery.
    Title: Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nicotinate-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
Names
nicotinamide mononucleotide adenylyltransferase 3
NP_001382630.1
NP_001382631.1
XP_038937700.1
XP_038937702.1
XP_038937703.1
XP_063121871.1
XP_063121872.1
XP_063121873.1
XP_063121874.1
XP_063121875.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395701.1 → NP_001382630.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I2B1, F7F588
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  2. NM_001395702.1 → NP_001382631.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I2B1, F7F588
    Related
    ENSRNOP00000018411.5, ENSRNOT00000018411.8
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    107771124..107888528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081775.2 → XP_038937703.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X6

    Conserved Domains (1) summary
    cl00015
    Location:26 → 117
    nt_trans; nucleotidyl transferase superfamily

  2. XM_039081772.2 → XP_038937700.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X3

    Conserved Domains (1) summary
    cl00015
    Location:26 → 163
    nt_trans; nucleotidyl transferase superfamily

  3. XM_063265801.1 → XP_063121871.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A6I2B1, F7F588

  4. XM_063265802.1 → XP_063121872.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A6I2B1, F7F588

  5. XM_063265805.1 → XP_063121875.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X7

  6. XM_063265804.1 → XP_063121874.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X4

  7. XM_063265803.1 → XP_063121873.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNV6

  8. XM_039081774.2 → XP_038937702.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X5

    Conserved Domains (1) summary
    cl00015
    Location:17 → 122
    nt_trans; nucleotidyl transferase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013224.2: Suppressed sequence

    Description
    NM_001013224.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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