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Ncapg2 non-SMC condensin II complex, subunit G2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362798, updated on 2-Nov-2024

Summary

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Official Symbol
Ncapg2provided by RGD
Official Full Name
non-SMC condensin II complex, subunit G2provided by RGD
Primary source
RGD:1308406
See related
EnsemblRapid:ENSRNOG00000004968 AllianceGenome:RGD:1308406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Luzp5; RGD1308406
Summary
Predicted to enable bHLH transcription factor binding activity and methylated histone binding activity. Predicted to be involved in mitotic sister chromatid segregation; positive regulation of chromosome segregation; and positive regulation of chromosome separation. Predicted to act upstream of with a positive effect on erythrocyte differentiation. Predicted to act upstream of with a negative effect on transcription by RNA polymerase II. Predicted to act upstream of or within inner cell mass cell proliferation. Predicted to be located in condensed nuclear chromosome and nuclear speck. Predicted to be part of condensin complex. Predicted to be active in nucleus. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 134.2), Spleen (RPKM 94.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncapg2 in Genome Data Viewer
Location:
6q33
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143484651..143561850)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137342449..137418083)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144291313..144362454)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32, pseudogene 17 Neighboring gene uncharacterized LOC134479490 Neighboring gene extended synaptotagmin 2 Neighboring gene uncharacterized LOC102548847 Neighboring gene uncharacterized LOC120093226 Neighboring gene protein tyrosine phosphatase, receptor type N2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. More than blood, a novel gene required for mammalian postimplantation development. Smith ED, et al. Mol Cell Biol, 2004 Feb. PMID 14729962, Free PMC Article
  2. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Xu Y, et al. Leukemia, 2006 Jul. PMID 16673016
  3. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Liu W, et al. Nature, 2010 Jul 22. PMID 20622854, Free PMC Article
  4. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Lee J, et al. Mol Biol Cell, 2011 Sep. PMID 21795393, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
condensin-2 complex subunit G2
Names
leucine zipper protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427667.1 → NP_001414596.1  condensin-2 complex subunit G2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000107065.1, ENSRNOT00000141893.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    143484651..143561850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262159.1 → XP_063118229.1  condensin-2 complex subunit G2 isoform X4

  2. XM_063262158.1 → XP_063118228.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2

  3. XM_063262156.1 → XP_063118226.1  condensin-2 complex subunit G2 isoform X1

  4. XM_063262157.1 → XP_063118227.1  condensin-2 complex subunit G2 isoform X2

  5. XM_039078085.2 → XP_038934013.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  6. XM_039078086.2 → XP_038934014.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Related
    ENSRNOP00000106240.1, ENSRNOT00000157778.1
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  7. XM_039078084.2 → XP_038934012.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  8. XM_063262160.1 → XP_063118230.1  condensin-2 complex subunit G2 isoform X5

  9. XM_039078080.2 → XP_038934008.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  10. XM_343124.10 → XP_343125.5  condensin-2 complex subunit G2 isoform X5

    See identical proteins and their annotated locations for XP_343125.5

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (2) summary
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]

  11. XM_039078083.2 → XP_038934011.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  12. XM_063262161.1 → XP_063118231.1  condensin-2 complex subunit G2 isoform X5

  13. XM_063262162.1 → XP_063118232.1  condensin-2 complex subunit G2 isoform X5

  14. XM_039078081.2 → XP_038934009.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  15. XM_039078089.2 → XP_038934017.1  condensin-2 complex subunit G2 isoform X6

    Conserved Domains (3) summary
    COG5096
    Location:258 → 403
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:296 → 324
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:132 → 280
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  16. XM_039078087.2 → XP_038934015.1  condensin-2 complex subunit G2 isoform X3

    UniProtKB/TrEMBL
    D4AAL2
    Conserved Domains (3) summary
    COG5096
    Location:338 → 483
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:212 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

RNA

  1. XR_010052125.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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