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Traf3 Tnf receptor-associated factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362788, updated on 2-Nov-2024

Summary

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Official Symbol
Traf3provided by RGD
Official Full Name
Tnf receptor-associated factor 3provided by RGD
Primary source
RGD:1304633
See related
EnsemblRapid:ENSRNOG00000008145 AllianceGenome:RGD:1304633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including regulation of defense response; regulation of type I interferon production; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of CD40 receptor complex. Predicted to be active in endosome membrane and mitochondrion. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 119.1), Spleen (RPKM 80.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Traf3 in Genome Data Viewer
Location:
6q32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136025097..136128363)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130199696..130307168)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135610698..135720247)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene REST corepressor 1 Neighboring gene uncharacterized LOC134479479 Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. Wang D, et al. Stem Cells Dev, 2020 Jun 1. PMID 32111144
  2. Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury. Wu Y, et al. J Mol Histol, 2014 Oct. PMID 24803166
  3. Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination. Zhang Y, et al. Balkan Med J, 2023 May 8. PMID 37000116, Free PMC Article
  4. ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis. Li J, et al. J Biochem Mol Toxicol, 2024 Apr. PMID 38605440
  5. Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells. Yu W, et al. Dig Dis Sci, 2021 Dec. PMID 33405047

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis.
    Title: ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis.
  2. Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination.
    Title: Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination.
  3. Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells.
    Title: Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells.
  4. TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
    Title: TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
  5. Rela and Traf3 were both targeted by miR-155-5p.
    Title: miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3.
  6. Data indicate a striking upregulation of TNF receptor associated factor 3 (TRAF3) after spinal cord injury (SCI).
    Title: Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.
  7. Dominant-negative forms of TRAF2 and TRAF3 inhibited but did not fully block LMP1-mediated transformation.
    Title: Unique signaling properties of CTAR1 in LMP1-mediated transformation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CD40 receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TNF receptor-associated factor 3
NP_001382041.1
XP_038968511.1
XP_038968512.1
XP_038968513.1
XP_038968516.1
XP_038968517.1
XP_038968518.1
XP_038968519.1
XP_038968520.1
XP_063118217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395112.1 → NP_001382041.1  TNF receptor-associated factor 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136025097..136128363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112591.2 → XP_038968519.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  2. XM_039112585.2 → XP_038968513.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Related
    ENSRNOP00000111538.1, ENSRNOT00000127387.1
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  3. XM_039112589.2 → XP_038968517.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Related
    ENSRNOP00000010906.6, ENSRNOT00000010906.8
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  4. XM_039112588.2 → XP_038968516.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  5. XM_039112592.2 → XP_038968520.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  6. XM_039112590.2 → XP_038968518.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARU4, A6KBQ0, D3Z9G0
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  7. XM_063262147.1 → XP_063118217.1  TNF receptor-associated factor 3 isoform X3

    UniProtKB/TrEMBL
    A6KBQ0, D3Z9G0

  8. XM_039112583.2 → XP_038968511.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7X2, A0A8I6ARU4
    Related
    ENSRNOP00000074381.1, ENSRNOT00000077770.3
    Conserved Domains (5) summary
    COG1196
    Location:294 → 475
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:420 → 605
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178 → 234
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:93 → 134
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:239 → 289
    zf-TRAF; TRAF-type zinc finger

  9. XM_039112584.2 → XP_038968512.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ARU4
    Related
    ENSRNOP00000094542.2, ENSRNOT00000108306.2
    Conserved Domains (4) summary
    COG1196
    Location:269 → 450
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:395 → 580
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:178 → 234
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:93 → 134
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108724.2: Suppressed sequence

    Description
    NM_001108724.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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