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Alg6 ALG6, alpha-1,3-glucosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362547, updated on 2-Nov-2024

Summary

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Official Symbol
Alg6provided by RGD
Official Full Name
ALG6, alpha-1,3-glucosyltransferaseprovided by RGD
Primary source
RGD:1308815
See related
EnsemblRapid:ENSRNOG00000009045 AllianceGenome:RGD:1308815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 51.9), Kidney (RPKM 51.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alg6 in Genome Data Viewer
Location:
5q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119520415..119606365)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114404972..114454440)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118415680..118470634)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556374 Neighboring gene forkhead box D3 Neighboring gene uncharacterized LOC134479015 Neighboring gene integrin subunit beta 3 binding protein Neighboring gene EF-hand calcium binding domain 7 Neighboring gene phosphoglucomutase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic. Westphal V, et al. Mol Genet Metab, 2000 Jul. PMID 10924277
  2. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. Imbach T, et al. Proc Natl Acad Sci U S A, 1999 Jun 8. PMID 10359825, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC124652

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Names
asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)
asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog
asparagine-linked glycosylation protein 6 homolog
dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
NP_001028881.1
XP_038966196.1
XP_038966197.1
XP_063144018.1
XP_063144019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033709.1 → NP_001028881.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

    See identical proteins and their annotated locations for NP_001028881.1

    Status: PROVISIONAL

    Source sequence(s)
    BC101850
    UniProtKB/Swiss-Prot
    Q3T1L5
    UniProtKB/TrEMBL
    F1LMD6
    Related
    ENSRNOP00000093347.2, ENSRNOT00000107656.2
    Conserved Domains (1) summary
    pfam03155
    Location:32 → 485
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    119520415..119606365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287948.1 → XP_063144018.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

  2. XM_063287949.1 → XP_063144019.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

    Related
    ENSRNOP00000109337.1, ENSRNOT00000133198.1

  3. XM_039110268.1 → XP_038966196.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

    UniProtKB/TrEMBL
    F1LMD6
    Related
    ENSRNOP00000012052.9, ENSRNOT00000012052.9
    Conserved Domains (1) summary
    pfam03155
    Location:98 → 521
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  4. XM_039110269.2 → XP_038966197.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:98 → 371
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3T1L5.1 GenPept UniProtKB/Swiss-Prot:Q3T1L5

Gene LinkOut

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