Sirt2 sirtuin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361532, updated on 2-Nov-2024

Summary

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Official Symbol: Sirt2provided by RGD
Official Full Name: sirtuin 2provided by RGD
Primary source: RGD:621481
See related: EnsemblRapid:ENSRNOG00000020102 AllianceGenome:RGD:621481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 274.8), Muscle (RPKM 207.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Sirt2 in Genome Data Viewer

Location:: 1q21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93181472..93204499)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84053883..84076975)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (86948866..86971954)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury.
Title: microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury.
SIRT2 overexpression decreases remifentanil-stimulated post-surgical hyperalgesia via microglia.
Title: SIRT2 overexpression decreases remifentanil-stimulated post-surgical hyperalgesia via microglia.
Inhibiting silence information regulator 2 and glutaminase in the amygdala can improve social behavior in autistic rats.
Title: Inhibiting silence information regulator 2 and glutaminase in the amygdala can improve social behavior in autistic rats.
SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.
Title: SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.
Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression.
Title: Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression.
SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin.
Title: SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin.
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
Title: PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro.
Title: SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro.
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Title: SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development.
Title: Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone H4K16 deacetylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone H4K16 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone H4K16 deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD-dependent histone deacetylase activity	IEA Inferred from Electronic Annotation more info
NOT enables NAD-dependent histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein demyristoylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein demyristoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein demyristoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein depalmitoylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein depalmitoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein depalmitoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin deacetylase activity	IEA Inferred from Electronic Annotation more info
NOT enables tubulin deacetylase activity	ISO Inferred from Sequence Orthology more info
enables tubulin deacetylase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to caloric restriction	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caloric restriction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caloric restriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epinephrine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
involved_in myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of striated muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine deacetylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tubulin deacetylation	IEA Inferred from Electronic Annotation more info
NOT involved_in tubulin deacetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in Schmidt-Lanterman incisure	IEA Inferred from Electronic Annotation more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in lateral loop	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
located_in meiotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in paranodal junction	IDA Inferred from Direct Assay more info	PubMed
located_in paranodal junction	IEA Inferred from Electronic Annotation more info
located_in paranodal junction	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	ISS Inferred from Sequence or Structural Similarity more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal loop	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-2

Names: 5E5 antigen; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2

NP_001386559.1

EC 2.3.1.286

NP_001386560.1

EC 2.3.1.286

XP_063122487.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399630.1 → NP_001386559.1 NAD-dependent protein deacetylase sirtuin-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8L2UN46, A6J9K9

Related

ENSRNOP00000080491.2, ENSRNOT00000095928.2
NM_001399631.1 → NP_001386560.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000059450.3, ENSRNOT00000064153.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93181472..93204499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266417.1 → XP_063122487.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1

Related

ENSRNOP00000107408.1, ENSRNOT00000151497.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008368.1: Suppressed sequence

Description

NM_001008368.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NM_053737.1: Suppressed sequence

Description

NM_053737.1: This RefSeq was removed because the source organism cannot be confirmed.