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Gab1 GRB2-associated binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361388, updated on 2-Nov-2024

Summary

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Official Symbol
Gab1provided by RGD
Official Full Name
GRB2-associated binding protein 1provided by RGD
Primary source
RGD:1311085
See related
EnsemblRapid:ENSRNOG00000017879 AllianceGenome:RGD:1311085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling adaptor activity. Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction. Predicted to be active in cell cortex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 124.9), Kidney (RPKM 123.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gab1 in Genome Data Viewer
Location:
19q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (44035693..44143617)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (27131262..27239236)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (30794290..30903819)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 38 Neighboring gene ribosomal protein L35, pseudogene 11 Neighboring gene uncharacterized LOC120098604 Neighboring gene uncharacterized LOC134483632 Neighboring gene uncharacterized LOC120098602 Neighboring gene SNF2 related chromatin remodeling ATPase 5 Neighboring gene FRAS1 related extracellular matrix 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Su D, et al. Biomed Pharmacother, 2017 Sep. PMID 28738535
  2. Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association. Dixit M, et al. Circ Res, 2003 Nov 14. PMID 14551245
  3. Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules. Hoffmann KM, et al. Cell Signal, 2006 Jul. PMID 16185843
  4. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Itoh M, et al. Mol Cell Biol, 2000 May. PMID 10779359, Free PMC Article
  5. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. Cherif M, et al. Biomed Res Int, 2015. PMID 26090437, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
    Title: Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
  2. A novel role of GAB1 and its down-stream signaling PI3K/AKT.
    Title: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis.
  3. using an in vitro model, we demonstrated that overexpressing Gab1 in neonatal cardiomyocytes, under hypoxic condition, resulted in the reduction of apoptosis suggesting a role for this protein in cardiomyocyte survival
    Title: Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes.
  4. While EGF activated Gab1 and Shc equally, within the same concentration range, HGF very potently and almost exclusively activated Gab1, having only a minimal effect on Shc
    Title: The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes.
  5. Report role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
    Title: A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
  6. role of Grb2-associated binder-1 (Gab1) in signaling pathways downstream of growth factor receptors.
    Title: Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
  7. Gab1 activation plays a central role in HGF's ability to stimulate intracellular transduction cascades in pancreatic acinar cells and this action likely plays a key role in HGF's ability to alter pancreatic cell function (i.e., growth/regeneration).
    Title: Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
  8. Gab1, considered a physiological activator of protein tyrosine phosphatase SHP2, increases cell motility in the presence but not the absence of insulin.
    Title: Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within labyrinthine layer development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hepatocyte growth factor IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GRB2-associated-binding protein 1
Names
growth factor receptor bound protein 2-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108444.1 → NP_001101914.1  GRB2-associated-binding protein 1

    See identical proteins and their annotated locations for NP_001101914.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A0A0G2JZD5, A6IYG9, C6JUQ2
    Related
    ENSRNOP00000102564.1, ENSRNOT00000169434.1
    Conserved Domains (2) summary
    cd01266
    Location:3 → 125
    PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain
    pfam00169
    Location:6 → 115
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    44035693..44143617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097824.2 → XP_038953752.1  GRB2-associated-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZD5, C6JUQ2
    Conserved Domains (1) summary
    cl17171
    Location:1 → 22
    PH-like; Pleckstrin homology-like domain

  2. XM_039097821.2 → XP_038953749.1  GRB2-associated-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZD5, C6JUQ2, D3ZAL7
    Related
    ENSRNOP00000024390.4, ENSRNOT00000024390.7
    Conserved Domains (1) summary
    cd01266
    Location:3 → 125
    PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain

  3. XM_063278117.1 → XP_063134187.1  GRB2-associated-binding protein 1 isoform X3

  4. XM_039097823.2 → XP_038953751.1  GRB2-associated-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZD5, C6JUQ2
    Conserved Domains (1) summary
    cl17171
    Location:1 → 22
    PH-like; Pleckstrin homology-like domain

  5. XM_063278118.1 → XP_063134188.1  GRB2-associated-binding protein 1 isoform X4

    Related
    ENSRNOP00000071006.3, ENSRNOT00000083219.3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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