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Cul2 cullin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361258, updated on 2-Nov-2024

Summary

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Official Symbol
Cul2provided by RGD
Official Full Name
cullin 2provided by RGD
Primary source
RGD:1310644
See related
EnsemblRapid:ENSRNOG00000015292 AllianceGenome:RGD:1310644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within protein catabolic process. Part of VCB complex. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 150.4), Brain (RPKM 115.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cul2 in Genome Data Viewer
Location:
17q12.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58864274..58905447, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54169093..54210197, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56952480..56992716, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930596D02 gene like 2 Neighboring gene BMP and activin membrane-bound inhibitor Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene uncharacterized LOC108348578 Neighboring gene cAMP responsive element modulator Neighboring gene marker of proliferation Ki-67, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Ohh M, et al. EMBO Rep, 2002 Feb. PMID 11818338, Free PMC Article
  2. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, et al. Oncogene, 2004 Mar 15. PMID 15021886
  3. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Pause A, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122164, Free PMC Article
  4. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, et al. J Cell Physiol, 2010 Mar. PMID 19950214
  5. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL. Physiology (Bethesda), 2009 Apr. PMID 19364912

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of VCB complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cullin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399213.1 → NP_001386142.1  cullin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6G8I6
    Related
    ENSRNOP00000061765.2, ENSRNOT00000066805.4
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    58864274..58905447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254073.5 → XP_006254135.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_006254135.1

    UniProtKB/TrEMBL
    A0A8I6G8I6, A6K9G9, D4A0H4
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_017600628.3 → XP_017456117.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G8I6, A6K9G9, D4A0H4
    Related
    ENSRNOP00000074075.2, ENSRNOT00000079607.3
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108417.1: Suppressed sequence

    Description
    NM_001108417.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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