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Bphl biphenyl hydrolase like [ Rattus norvegicus (Norway rat) ]

Gene ID: 361239, updated on 17-Aug-2024

Summary

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Official Symbol
Bphlprovided by RGD
Official Full Name
biphenyl hydrolase likeprovided by RGD
Primary source
RGD:1307572
See related
EnsemblRapid:ENSRNOG00000017577 AllianceGenome:RGD:1307572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-amino-acid esterase activity and poly(ADP-ribose) glycohydrolase activity. Predicted to be involved in ATP generation from poly-ADP-D-ribose. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 355.4), Liver (RPKM 179.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bphl in Genome Data Viewer
Location:
17p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31006283..31042631, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30800939..30837277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (31498877..31535172, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2A class IIa like 1 Neighboring gene tubulin, beta 2A class IIa Neighboring gene receptor interacting serine/threonine kinase 1 Neighboring gene serpin family B member 6A Neighboring gene N-ribosyldihydronicotinamide:quinone dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation. Putt KS, et al. Anal Biochem, 2004 Oct 15. PMID 15450800
  2. Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells. Bernardi R, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074616
  3. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Wright RH, et al. Science, 2016 Jun 3. PMID 27257257
  4. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Rosenthal F, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474714
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125077

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-amino-acid esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(ADP-ribose) glycohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
valacyclovir hydrolase
Names
biphenyl hydrolase-like (serine hydrolase)
biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037206.1 → NP_001032283.1  valacyclovir hydrolase

    See identical proteins and their annotated locations for NP_001032283.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105908
    UniProtKB/TrEMBL
    F7FBS0, Q3B8N9
    Related
    ENSRNOP00000023914.6, ENSRNOT00000023914.8
    Conserved Domains (1) summary
    COG0596
    Location:44 → 291
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    31006283..31042631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276588.1 → XP_063132658.1  valacyclovir hydrolase isoform X4

  2. XM_063276586.1 → XP_063132656.1  valacyclovir hydrolase isoform X1

  3. XM_039095883.1 → XP_038951811.1  valacyclovir hydrolase isoform X3

    UniProtKB/TrEMBL
    A6J7G9
    Conserved Domains (1) summary
    COG0596
    Location:25 → 189
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  4. XM_063276587.1 → XP_063132657.1  valacyclovir hydrolase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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