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Kpna3 karyopherin subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361055, updated on 2-Nov-2024

Summary

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Official Symbol
Kpna3provided by RGD
Official Full Name
karyopherin subunit alpha 3provided by RGD
Primary source
RGD:1311339
See related
EnsemblRapid:ENSRNOG00000014945 AllianceGenome:RGD:1311339
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
importin
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 393.2), Heart (RPKM 129.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kpna3 in Genome Data Viewer
Location:
15p12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (39712375..39786127, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (35536310..35610066, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (41696356..41770112, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 11 Neighboring gene EBP like Neighboring gene ribosomal protein S20, pseudogene 1 Neighboring gene uncharacterized LOC120097005 Neighboring gene transfer RNA serine (anticodon AGA) 14 Neighboring gene uncharacterized LOC120097167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C/EBPα-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats. Chen WB, et al. Brain Res Bull, 2020 Nov. PMID 32814091
  2. Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock. Senol SP, et al. Inflamm Res, 2016 May. PMID 26875149
  3. Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Plant KE, et al. Pharmacogenet Genomics, 2006 Sep. PMID 16906019
  4. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. Kobayashi M, et al. J Biol Chem, 2002 Feb 22. PMID 11744694
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C/EBPalpha-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
    Title: C/EBPα-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
  2. The results suggest that an increase in the expression of PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and importin-alpha3 expression/activity participates in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation during endotoxemia and thus have a beneficial effect in septic shock treatment
    Title: Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
importin subunit alpha-4
Names
importin subunit alpha-3
karyopherin (importin) alpha 3
karyopherin alpha 3
predicted role in nuclear import

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014792.1 → NP_001014792.1  importin subunit alpha-4

    See identical proteins and their annotated locations for NP_001014792.1

    Status: PROVISIONAL

    Source sequence(s)
    AY779027
    UniProtKB/TrEMBL
    A0A8I5ZWC6, D3ZU98, Q56R18
    Related
    ENSRNOP00000032371.3, ENSRNOT00000034400.5
    Conserved Domains (2) summary
    COG5064
    Location:7 → 521
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:244 → 269
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    39712375..39786127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093504.1 → XP_038949432.1  importin subunit alpha-4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWC6, A6K6B9
    Conserved Domains (2) summary
    COG5064
    Location:1 → 497
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:220 → 245
    ARM; armadillo repeat [structural motif]

  2. XM_006252127.4 → XP_006252189.1  importin subunit alpha-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWC6
    Related
    ENSRNOP00000084014.1, ENSRNOT00000106096.2
    Conserved Domains (4) summary
    COG5064
    Location:43 → 539
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:260 → 373
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:43 → 111
    IBB; Importin beta binding domain
    sd00043
    Location:262 → 287
    ARM; armadillo repeat [structural motif]

  3. XM_063274414.1 → XP_063130484.1  importin subunit alpha-4 isoform X2

    UniProtKB/TrEMBL
    A6K6B9

  4. XM_039093503.1 → XP_038949431.1  importin subunit alpha-4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWC6, A6K6B9
    Related
    ENSRNOP00000093015.1, ENSRNOT00000111588.2
    Conserved Domains (2) summary
    COG5064
    Location:1 → 497
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:220 → 245
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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