Stx18 syntaxin 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx18provided by RGD
Official Full Name: syntaxin 18provided by RGD
Primary source: RGD:1310058
See related: EnsemblRapid:ENSRNOG00000006139 AllianceGenome:RGD:1310058
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of ER to Golgi vesicle-mediated transport; regulation of organelle organization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 179.1), Kidney (RPKM 125.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (76883767..76976442, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (72670683..72761423, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (77402952..77492910, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE118559 (e-PCR)
- UniSTS:248844

RH127466 (e-PCR)
- UniSTS:210776

RH124640 (e-PCR)
- UniSTS:161462

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum membrane organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ER to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: syntaxin-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012151.1 → NP_001012151.1 syntaxin-18

See identical proteins and their annotated locations for NP_001012151.1

Status: PROVISIONAL

Source sequence(s)

BC079183

UniProtKB/Swiss-Prot

Q68FW4

UniProtKB/TrEMBL

A0A8I6G3N6, A6IJV2

Related

ENSRNOP00000082982.1, ENSRNOT00000095745.2

Conserved Domains (2) summary

cd15850
Location:245 → 303

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 96

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus