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Msi2 musashi RNA-binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360596, updated on 2-Nov-2024

Summary

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Official Symbol
Msi2provided by RGD
Official Full Name
musashi RNA-binding protein 2provided by RGD
Primary source
RGD:1560397
See related
EnsemblRapid:ENSRNOG00000025338 AllianceGenome:RGD:1560397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560397
Summary
Predicted to enable identical protein binding activity; mRNA binding activity; and poly(U) RNA binding activity. Predicted to be involved in central nervous system development; regulation of translation; and stem cell development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 252.4), Muscle (RPKM 249.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Msi2 in Genome Data Viewer
Location:
10q26
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73640960..74007497, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73143760..73510566, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75673840..76040106, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557529 Neighboring gene coiled-coil domain containing 182 Neighboring gene uncharacterized LOC134480852 Neighboring gene uncharacterized LOC134480853 Neighboring gene uncharacterized LOC134480854 Neighboring gene uncharacterized LOC134480855 Neighboring gene A-kinase anchoring protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Sakakibara S, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12407178, Free PMC Article
  2. Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease. Sengupta U, et al. Acta Neuropathol Commun, 2018 Oct 26. PMID 30367664, Free PMC Article
  3. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. Sakakibara S, et al. J Neurosci, 2001 Oct 15. PMID 11588182, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 2; musashi RNA-binding protein 2
Names
Musashi homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430232.1 → NP_001417161.1  musashi RNA-binding protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  2. NM_001430233.1 → NP_001417162.1  musashi RNA-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AQW7

  3. NM_001430234.1 → NP_001417163.1  musashi RNA-binding protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_001430235.1 → NP_001417164.1  musashi RNA-binding protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  5. NM_001430236.1 → NP_001417165.1  musashi RNA-binding protein 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  6. NM_001430237.1 → NP_001417166.1  musashi RNA-binding protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  7. NM_001430238.1 → NP_001417167.1  musashi RNA-binding protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  8. NM_001430239.1 → NP_001417168.1  musashi RNA-binding protein 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    73640960..74007497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087672.2 → XP_038943600.1  RNA-binding protein Musashi homolog 2 isoform X11

    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  2. XM_039087667.2 → XP_038943595.1  RNA-binding protein Musashi homolog 2 isoform X6

    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  3. XM_039087663.2 → XP_038943591.1  RNA-binding protein Musashi homolog 2 isoform X3

    Related
    ENSRNOP00000096507.1, ENSRNOT00000099554.2
    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  4. XM_039087669.2 → XP_038943597.1  RNA-binding protein Musashi homolog 2 isoform X10

    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  5. XM_039087661.2 → XP_038943589.1  RNA-binding protein Musashi homolog 2 isoform X2

    Conserved Domains (3) summary
    TIGR01628
    Location:35 → 339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  6. XM_063270136.1 → XP_063126206.1  RNA-binding protein Musashi homolog 2 isoform X7

  7. XM_063270135.1 → XP_063126205.1  RNA-binding protein Musashi homolog 2 isoform X4

    Related
    ENSRNOP00000090730.2, ENSRNOT00000106986.2

  8. XM_039087664.2 → XP_038943592.1  RNA-binding protein Musashi homolog 2 isoform X5

    UniProtKB/TrEMBL
    A6HHY1
    Conserved Domains (3) summary
    TIGR01628
    Location:35 → 333
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  9. XM_063270134.1 → XP_063126204.1  RNA-binding protein Musashi homolog 2 isoform X1

    Related
    ENSRNOP00000087497.2, ENSRNOT00000112171.2

  10. XM_017597690.3 → XP_017453179.1  RNA-binding protein Musashi homolog 2 isoform X13

    UniProtKB/TrEMBL
    A0A8I6AAP6

  11. XM_039087674.2 → XP_038943602.1  RNA-binding protein Musashi homolog 2 isoform X12

    Conserved Domains (2) summary
    TIGR01628
    Location:60 → 275
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:59 → 108
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_039087676.2 → XP_038943604.1  RNA-binding protein Musashi homolog 2 isoform X14

    UniProtKB/TrEMBL
    A0A8I6AAP6
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 212
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. XM_063270138.1 → XP_063126208.1  RNA-binding protein Musashi homolog 2 isoform X9

  14. XM_063270137.1 → XP_063126207.1  RNA-binding protein Musashi homolog 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GG20
    Related
    ENSRNOP00000107092.1, ENSRNOT00000153490.1
Nucleotide Protein Strain
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