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Dusp14 dual specificity phosphatase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360580, updated on 18-Sep-2024

Summary

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Official Symbol
Dusp14provided by RGD
Official Full Name
dual specificity phosphatase 14provided by RGD
Primary source
RGD:1307415
See related
EnsemblRapid:ENSRNOG00000030091 AllianceGenome:RGD:1307415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dusp14l2
Summary
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 111.4), Brain (RPKM 75.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dusp14 in Genome Data Viewer
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69433949..69463863, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68936483..68966347, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71363688..71383602, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480841 Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839 Neighboring gene ribosomal protein S15a, pseudogene 2 Neighboring gene transcriptional adaptor 2A Neighboring gene similar to human chromosome 17 open reading frame 78 Neighboring gene acetyl-CoA carboxylase alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis. Zhao Z, et al. Bioengineered, 2021 Dec. PMID 34605731, Free PMC Article
  2. The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Galvao J, et al. Invest Ophthalmol Vis Sci, 2018 Jun 1. PMID 29860460, Free PMC Article
  3. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, et al. Genomics, 2007 Mar. PMID 17218081, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis.
    Title: Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis.
  2. These results link intrinsic and extrinsic regulators of axon growth and suggest modulation of the KLF9-Dusp14 pathway as a potential approach to improve regeneration in the adult CNS after injury.
    Title: The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 14
Names
dual specificity phosphatase 14-like 2
NP_001073362.1
NP_001257764.1
NP_001257765.1
XP_038942286.1
XP_038942287.1
XP_038942288.1
XP_038942289.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079893.3 → NP_001073362.1  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_001073362.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

  2. NM_001270835.2 → NP_001257764.1  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_001257764.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Related
    ENSRNOP00000068350.3, ENSRNOT00000077025.4
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

  3. NM_001270836.2 → NP_001257765.1  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_001257765.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Related
    ENSRNOP00000073504.1, ENSRNOT00000083300.3
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    69433949..69463863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086361.2 → XP_038942289.1  dual specificity protein phosphatase 14 isoform X2

  2. XM_039086359.1 → XP_038942287.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Related
    ENSRNOP00000106797.1, ENSRNOT00000161103.1
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

  3. XM_039086358.2 → XP_038942286.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

  4. XM_039086360.2 → XP_038942288.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/TrEMBL
    A1EC97, A6HHJ9, A6HHK0
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14
Nucleotide Protein Strain
Heading Accession and Version

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