Nlrp1a NLR family, pyrin domain containing 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp1aprovided by RGD
Official Full Name: NLR family, pyrin domain containing 1Aprovided by RGD
Primary source: RGD:1310963
See related: EnsemblRapid:ENSRNOG00000023143 AllianceGenome:RGD:1310963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nalp1; Nlrp1
Summary: Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 161.4), Spleen (RPKM 147.0) and 8 other tissues See more
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Genomic context

Location:: 10q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (56277134..56332229, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55778560..55833639, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57692474..57747608, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease.
Title: Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease.
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3beta Overactivation-Induced Hyperphosphorylated Tau in Rats.
Title: Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
NLRP1 promoted myofibroblast differentiation and excessive ECM production in TGF-beta1-induced neonatal cardiac fibroblasts through directly targeting TGF-beta1/Smad signaling pathways.
Title: NLRP1 promotes TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts.
Inflammasome caspase-1 IL-1beta platform is involved in chronic constriction injury (CCI)-induced neuropathic pain and in lipoxin-induced analgesia.
Title: Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia.
The NOD-like receptor NLRP1a/Caspase-1 pathway is the best candidate to mediate the parasite-induced cell death.
Title: A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.
Hyperglycemia induces neuroinflammation through activation of NLRP1 inflammasome.
Title: Nod-like receptor protein 1 inflammasome mediates neuron injury under high glucose.
Our findings reveal Toxoplasma as a novel activator of the NLRP1 inflammasome in rat macrophages.
Title: Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.
Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1beta production in acute glaucoma.
Title: Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.
Age-related cognitive decline may involve a heightened inflammatory response associated with activation of the NLRP1 inflammasome in the hippocampus.
Title: Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NLRP1 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cellular defense response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pyroptotic inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP1 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 1a allele 1

Names: NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT, leucine rich repeat and PYD containing 1; NLR family protein 1; NLR family, pyrin domain containing 1; resistant anthrax lethal toxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145755.2 → NP_001139227.2 NACHT, LRR and PYD domains-containing protein 1a allele 1

See identical proteins and their annotated locations for NP_001139227.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A0A0G2QC28, D9I2F9, D9I2G3, F1LPA5

Related

ENSRNOP00000091173.1, ENSRNOT00000094927.2

Conserved Domains (7) summary

cd08330
Location:1128 → 1208

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:674 → 695

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:176 → 344

NACHT; NACHT domain

pfam13553
Location:856 → 1108

FIIND; Function to find

pfam17776
Location:470 → 581

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:414 → 468

NOD2_WH; NOD2 winged helix domain

cl39015
Location:664 → 785

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

56277134..56332229 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086323.2 → XP_038942251.1 NACHT, LRR and PYD domains-containing protein 1a allele 1 isoform X2

UniProtKB/Swiss-Prot

D9I2H0

Related

ENSRNOP00000073609.3, ENSRNOT00000082171.3

Conserved Domains (7) summary

cd08330
Location:1110 → 1190

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:656 → 677

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:158 → 326

NACHT; NACHT domain

pfam13553
Location:838 → 1090

FIIND; Function to find

pfam17776
Location:452 → 563

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:396 → 450

NOD2_WH; NOD2 winged helix domain

cl39015
Location:646 → 767

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006246755.5 → XP_006246817.1 NACHT, LRR and PYD domains-containing protein 1a allele 1 isoform X1

See identical proteins and their annotated locations for XP_006246817.1

UniProtKB/Swiss-Prot

A0A0G2QC28, D9I2F9, D9I2G3, F1LPA5

Conserved Domains (7) summary

cd08330
Location:1128 → 1208

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:674 → 695

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:176 → 344

NACHT; NACHT domain

pfam13553
Location:856 → 1108

FIIND; Function to find

pfam17776
Location:470 → 581

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:414 → 468

NOD2_WH; NOD2 winged helix domain

cl39015
Location:664 → 785

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039086324.2 → XP_038942252.1 NACHT, LRR and PYD domains-containing protein 1a allele 1 isoform X3

UniProtKB/Swiss-Prot

D9I2G3

Related

ENSRNOP00000108659.1, ENSRNOT00000130107.1

Conserved Domains (7) summary

cd08330
Location:1108 → 1188

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:654 → 675

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:156 → 324

NACHT; NACHT domain

pfam13553
Location:836 → 1088

FIIND; Function to find

pfam17776
Location:450 → 561

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:394 → 448

NOD2_WH; NOD2 winged helix domain

cl39015
Location:644 → 765

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039086325.2 → XP_038942253.1 NACHT, LRR and PYD domains-containing protein 1a allele 1 isoform X4

Conserved Domains (5) summary

sd00033
Location:674 → 695

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:176 → 344

NACHT; NACHT domain

pfam17776
Location:470 → 581

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:414 → 468

NOD2_WH; NOD2 winged helix domain

cl39015
Location:664 → 785

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

XR_005489886.2 RNA Sequence

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
D9I2F9.1	GenPept	UniProtKB/Swiss-Prot:D9I2F9
D9I2G1.1	GenPept	UniProtKB/Swiss-Prot:D9I2G1
D9I2G3.1	GenPept	UniProtKB/Swiss-Prot:D9I2G3
D9I2G4.1	GenPept	UniProtKB/Swiss-Prot:D9I2G4
D9I2H0.1	GenPept	UniProtKB/Swiss-Prot:D9I2H0