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Arhgdig Rho GDP dissociation inhibitor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 360500, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgdigprovided by RGD
Official Full Name
Rho GDP dissociation inhibitor gammaprovided by RGD
Primary source
RGD:1310739
See related
EnsemblRapid:ENSRNOG00000068707 AllianceGenome:RGD:1310739
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Predicted to act upstream of or within blastocyst hatching and regulation of protein localization. Predicted to be located in cytosol and plasma membrane. Orthologous to human ARHGDIG (Rho GDP dissociation inhibitor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Arhgdig in Genome Data Viewer
Location:
10q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15723525..15725719, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15219049..15221257, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene axin 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene protein disulfide isomerase family A, member 2 Neighboring gene regulator of G-protein signaling 11 Neighboring gene family with sequence similarity 234, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation. Sun J, et al. Atherosclerosis, 2023 Dec. PMID 38029612
  2. The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex. Liu W, et al. J Biol Chem, 2010 Feb 26. PMID 20051515, Free PMC Article
  3. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. Zalcman G, et al. J Biol Chem, 1996 Nov 29. PMID 8939998
  4. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
    Title: RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
  2. corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane
    Title: The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables Rho GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GDP-dissociation inhibitor 3
Names
Rho GDP dissociation inhibitor (GDI) gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108269.1 → NP_001101739.1  rho GDP-dissociation inhibitor 3

    See identical proteins and their annotated locations for NP_001101739.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I5ZRJ5, A6HD94
    Related
    ENSRNOP00000080805.1, ENSRNOT00000103181.2
    Conserved Domains (1) summary
    pfam02115
    Location:42 → 222
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15723525..15725719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086280.2 → XP_038942208.1  rho GDP-dissociation inhibitor 3 isoform X1

    Conserved Domains (1) summary
    pfam02115
    Location:42 → 216
    Rho_GDI; RHO protein GDP dissociation inhibitor
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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