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Gpr141 G protein-coupled receptor 141 [ Mus musculus (house mouse) ]

Gene ID: 353346, updated on 2-Nov-2024

Summary

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Official Symbol
Gpr141provided by MGI
Official Full Name
G protein-coupled receptor 141provided by MGI
Primary source
MGI:MGI:2672983
See related
Ensembl:ENSMUSG00000053101 AllianceGenome:MGI:2672983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR13
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Orthologous to human GPR141 (G protein-coupled receptor 141). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Gpr141 in Genome Data Viewer
Location:
13 A2; 13 7.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19933850..20008499, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19749680..19824336, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NME/NM23 family member 8 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19879801-19880102 Neighboring gene G protein-coupled receptor 141B Neighboring gene STARR-seq mESC enhancer starr_33802 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33803 Neighboring gene STARR-seq mESC enhancer starr_33804 Neighboring gene STARR-seq mESC enhancer starr_33805 Neighboring gene predicted gene 5446 Neighboring gene STARR-seq mESC enhancer starr_33809 Neighboring gene STARR-positive B cell enhancer ABC_E11780 Neighboring gene STARR-seq mESC enhancer starr_33810 Neighboring gene STARR-positive B cell enhancer ABC_E7207 Neighboring gene STARR-positive B cell enhancer ABC_E4052 Neighboring gene STARR-seq mESC enhancer starr_33811 Neighboring gene engulfment and cell motility 1 Neighboring gene STARR-positive B cell enhancer ABC_E5371 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:20299067-20299268 Neighboring gene STARR-seq mESC enhancer starr_33815 Neighboring gene STARR-seq mESC enhancer starr_33817 Neighboring gene STARR-seq mESC enhancer starr_33818 Neighboring gene predicted gene, 32036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. Sawabe A, et al. J Leukoc Biol, 2024 Apr 29. PMID 38226682
  2. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor.
    Title: The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables oxysterol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 141
Names
G-protein coupled receptor PGR13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181754.4 → NP_861419.3  probable G-protein coupled receptor 141

    See identical proteins and their annotated locations for NP_861419.3

    Status: VALIDATED

    Source sequence(s)
    AC122886, AC153016
    Consensus CDS
    CCDS26264.1
    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Related
    ENSMUSP00000066921.3, ENSMUST00000065335.3
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    19933850..20008499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516705.4 → XP_006516768.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_006516768.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_036158079.1 → XP_036013972.1  probable G-protein coupled receptor 141 isoform X1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006516704.4 → XP_006516767.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_006516767.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_011244316.3 → XP_011242618.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_011242618.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_006516703.4 → XP_006516766.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_006516766.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_011244315.3 → XP_011242617.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_011242617.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_011244313.3 → XP_011242615.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_011242615.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. XM_011244314.3 → XP_011242616.1  probable G-protein coupled receptor 141 isoform X1

    See identical proteins and their annotated locations for XP_011242616.1

    UniProtKB/Swiss-Prot
    Q059N8, Q7TQP0, Q80UC5
    UniProtKB/TrEMBL
    Q3U3M0
    Conserved Domains (2) summary
    cd14964
    Location:19 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:19 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQP0.1 GenPept UniProtKB/Swiss-Prot:Q7TQP0

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