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IGFBP4 insulin like growth factor binding protein 4 [ Homo sapiens (human) ]

Gene ID: 3487, updated on 3-Nov-2024

Summary

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Official Symbol
IGFBP4provided by HGNC
Official Full Name
insulin like growth factor binding protein 4provided by HGNC
Primary source
HGNC:HGNC:5473
See related
Ensembl:ENSG00000141753 MIM:146733; AllianceGenome:HGNC:5473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP-4; IBP4; IGFBP-4; HT29-IGFBP
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 316.3), ovary (RPKM 298.9) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See IGFBP4 in Genome Data Viewer
Location:
17q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40443450..40457725)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41306951..41321232)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38599702..38613977)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase II alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38573807-38574332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38575812-38576354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8493 Neighboring gene ribosomal protein L23a pseudogene 75 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627029-38627920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627921-38628810 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:38636369-38637568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38637551-38637736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38646739-38647364 Neighboring gene tensin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38649729-38650230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38650231-38650730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38655417-38656288 Neighboring gene uncharacterized LOC105371773 Neighboring gene Sharpr-MPRA regulatory region 2600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. Suzuki K, et al. J Reprod Immunol, 2006 Jun. PMID 16540175
  2. Insulin-like growth factor binding protein-4 expression is dependent on the carbohydrate in the media in HT-29 cells. Corkins MR, et al. Growth Horm IGF Res, 2002 Jun. PMID 12163000
  3. Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4. Son JW, et al. Mol Neurobiol, 2019 Nov. PMID 31081524
  4. Insulin-like growth factor (IGF)-independent effects of IGF binding protein-4 on human granulosa cell steroidogenesis. Wright RJ, et al. Biol Reprod, 2002 Sep. PMID 12193384
  5. Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells. Miyagawa I, et al. J Immunol, 2017 Sep 1. PMID 28724578

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
    Title: Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
  2. AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia.
    Title: AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia.
  3. Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.
    Title: Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.
  4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
    Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
  5. m[6]A mRNA methylation regulates the ERK/NF-kappaB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer.
    Title: m(6)A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer.
  6. PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Title: PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
  7. Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection.
    Title: Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection.
  8. Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
    Title: Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
  9. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
    Title: Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
  10. The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.
    Title: The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Using a yeast two-hybrid system, HIV-1 Tat has been shown to bind the human insulin-like growth factor binding protein 4, suggesting a role for this protein in mediating the biological activity of Tat during HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
insulin-like growth factor-binding protein 4
Names
IBP-4
IGF-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001552.3 → NP_001543.2  insulin-like growth factor-binding protein 4 precursor

    See identical proteins and their annotated locations for NP_001543.2

    Status: REVIEWED

    Source sequence(s)
    AC018629, BC016041, CN431519
    Consensus CDS
    CCDS11367.1
    UniProtKB/Swiss-Prot
    A0N9W2, B4E351, P22692, Q5U012, Q9UCL6
    Related
    ENSP00000269593.4, ENST00000269593.5
    Conserved Domains (2) summary
    smart00121
    Location:25 → 101
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:174 → 249
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40443450..40457725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41306951..41321232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22692.2 GenPept UniProtKB/Swiss-Prot:P22692

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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