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rhogb ras homolog family member Gb [ Danio rerio (zebrafish) ]

Gene ID: 336933, updated on 12-Sep-2024

Summary

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Official Symbol
rhogbprovided by ZNC
Official Full Name
ras homolog family member Gbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8877
See related
Ensembl:ENSDARG00000004301 AllianceGenome:ZFIN:ZDB-GENE-030131-8877
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ARHG; rhog; zgc:55848; wu:fk30f01
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within response to bacterium. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Is expressed in dorsal aorta; macrophage; somite 3; and somite 4. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rhogb in Genome Data Viewer
Location:
chromosome: 21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30937693..30951883)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30900998..30915188)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 7 Neighboring gene stromal interaction molecule 1b Neighboring gene uncharacterized LOC101886778 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene nuclear cap binding subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Promotion effect of liver tumor progression in male kras transgenic zebrafish induced by tris (1, 3-dichloro-2-propyl) phosphate. Chen S, et al. Ecotoxicol Environ Saf, 2020 Mar 15. PMID 31991394
  2. Progression of liver tumor was promoted by tris(1,3-dichloro-2-propyl) phosphate through the induction of inflammatory responses in kras(V12) transgenic zebrafish. Chen S, et al. Environ Pollut, 2019 Dec. PMID 31606661
  3. Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, et al. J Immunol, 2016 Dec 15. PMID 27837107, Free PMC Article
  4. Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Qian F, et al. Dev Dyn, 2005 Jul. PMID 15937927
  5. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras homolog family member Gb
Names
ras homolog gene family, member G (rho G)
ras homolog gene family, member Gb
rho G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200040.2 → NP_956334.1  ras homolog family member Gb

    See identical proteins and their annotated locations for NP_956334.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044508
    UniProtKB/TrEMBL
    B2GR44, Q803F2
    Related
    ENSDARP00000027635.6, ENSDART00000022562.7
    Conserved Domains (2) summary
    smart00174
    Location:6 → 179
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:1 → 191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    30937693..30951883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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