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Dock1 dedicator of cytokinesis 1 [ Mus musculus (house mouse) ]

Gene ID: 330662, updated on 2-Nov-2024

Summary

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Official Symbol
Dock1provided by MGI
Official Full Name
dedicator of cytokinesis 1provided by MGI
Primary source
MGI:MGI:2429765
See related
Ensembl:ENSMUSG00000058325 AllianceGenome:MGI:2429765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b3190Clo; 9130006G06Rik; D630004B07Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in several cellular components, including glutamatergic synapse; plasma membrane; and postsynapse. Is expressed in several structures, including dermomyotome; genitourinary system; heart; hemolymphoid system gland; and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.8), adrenal adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dock1 in Genome Data Viewer
Location:
7 F3; 7 79.14 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (134272416..134775376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134670687..135173647)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene inhibitory synaptic factor 2A Neighboring gene VISTA enhancer mm1401 Neighboring gene RIKEN cDNA 1700120G07 gene Neighboring gene STARR-seq mESC enhancer starr_20359 Neighboring gene predicted gene, 24581 Neighboring gene neuropeptide S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. Kiyokawa E, et al. J Biol Chem, 1998 Sep 18. PMID 9733740
  2. Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Li X, et al. Nat Neurosci, 2008 Jan. PMID 18066058, Free PMC Article
  3. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1. Tajiri H, et al. Cell Rep, 2017 May 2. PMID 28467910
  4. Rac1 is essential for basement membrane-dependent epiblast survival. He X, et al. Mol Cell Biol, 2010 Jul. PMID 20457815, Free PMC Article
  5. Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling. Bagci H, et al. Cell Death Dis, 2014 Aug 14. PMID 25118935, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
    Title: Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
  2. Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 coincide with a delay in the initiation of mammary gland involution.
    Title: Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.
  3. Dock1 and Dock5 are not the important exchange factors regulating Rac activity during the establishment and maintenance of the glomerular barrier
    Title: The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
  4. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis.
    Title: Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
  5. The phospholipase D-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.
    Title: Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.
  6. The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end.
    Title: The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.
  7. Results indicate that the combination of DOCK2 and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.
    Title: Role of DOCK2 and DOCK180 in fetal thymus colonization.
  8. Dock1 has an essential role in embryonic development.
    Title: The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 1
Names
180 kDa protein downstream of CRK
DOCK180
dedicator of cyto-kinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033420.2 → NP_001028592.1  dedicator of cytokinesis protein 1

    See identical proteins and their annotated locations for NP_001028592.1

    Status: VALIDATED

    Source sequence(s)
    AC100208, AC127574, AC129300, AC136515, AC136641
    Consensus CDS
    CCDS40166.1
    UniProtKB/Swiss-Prot
    Q3URT8, Q3UY80, Q4QQL8, Q6PD14, Q8BUR4, Q8BVC9, Q91Z55, Q922V1
    Related
    ENSMUSP00000081531.5, ENSMUST00000084488.5
    Conserved Domains (4) summary
    cd08694
    Location:424 → 619
    C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
    cd12051
    Location:13 → 68
    SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
    pfam16172
    Location:72 → 416
    DOCK_N; DOCK N-terminus
    cl06123
    Location:1214 → 1612
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    134272416..134775376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUR4.3 GenPept UniProtKB/Swiss-Prot:Q8BUR4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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