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Fcrl5 Fc receptor-like 5 [ Mus musculus (house mouse) ]

Gene ID: 329693, updated on 18-Sep-2024

Summary

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Official Symbol
Fcrl5provided by MGI
Official Full Name
Fc receptor-like 5provided by MGI
Primary source
MGI:MGI:3053558
See related
Ensembl:ENSMUSG00000048031 AllianceGenome:MGI:3053558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fcrh3; mBXMH2
Summary
Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within negative regulation of B cell receptor signaling pathway and negative regulation of release of sequestered calcium ion into cytosol. Located in plasma membrane. Orthologous to human FCRL5 (Fc receptor like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 2.7), thymus adult (RPKM 0.2) and 2 other tissues See more
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Genomic context

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See Fcrl5 in Genome Data Viewer
Location:
3 F1; 3 38.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87343084..87407985)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87435777..87500678)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31940 Neighboring gene STARR-positive B cell enhancer ABC_E10187 Neighboring gene STARR-positive B cell enhancer ABC_E9215 Neighboring gene STARR-positive B cell enhancer ABC_E3443 Neighboring gene Fc receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_08155 Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085 Neighboring gene STARR-positive B cell enhancer ABC_E7919 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87310398-87310698 Neighboring gene STARR-positive B cell enhancer ABC_E7920 Neighboring gene STARR-positive B cell enhancer ABC_E6067 Neighboring gene STARR-positive B cell enhancer ABC_E10189 Neighboring gene STARR-positive B cell enhancer ABC_E6068 Neighboring gene ets variant 3 Neighboring gene ets variant 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Haga CL, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17522256, Free PMC Article
  2. Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin. Campbell JA, et al. J Immunol, 2010 Jul 1. PMID 20519648, Free PMC Article
  3. Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Won WJ, et al. J Immunol, 2006 Nov 15. PMID 17082595
  4. Differential B cell expression of mouse Fc receptor homologs. Davis RS, et al. Int Immunol, 2004 Sep. PMID 15302849
  5. Species-specific evolution of the FcR family in endothermic vertebrates. Fayngerts SA, et al. Immunogenetics, 2007 Jun. PMID 17356879

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease.
    Title: Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease.
  2. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
    Title: FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
  3. The three amino-terminal immunoglobulin domains of FCRL5 are required for binding of orthopoxvirus histocompatibility class I-like protein to B cells and monocytes/macrophages.
    Title: Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin.
  4. Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.
    Title: Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.
  5. a novel immunoregulatory marker of splenic marginal zone and B1 type B lineage cells.
    Title: Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of B cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
Fc receptor-like protein 5
Names
BXMAS1-like protein 2
Fc receptor-like protein 3
fc receptor homolog 3
fcR-like protein 5
moFcRH3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113238.1 → NP_001106709.1  Fc receptor-like protein 5 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC163618, AY158090
    Consensus CDS
    CCDS50944.1
    UniProtKB/TrEMBL
    J3QJU0
    Related
    ENSMUSP00000141311.2, ENSMUST00000193229.6
    Conserved Domains (3) summary
    smart00410
    Location:222 → 305
    IG_like; Immunoglobulin like
    pfam13895
    Location:220 → 303
    Ig_2; Immunoglobulin domain
    cl11960
    Location:31 → 114
    Ig; Immunoglobulin domain

  2. NM_183222.3 → NP_899045.3  Fc receptor-like protein 5 isoform a precursor

    See identical proteins and their annotated locations for NP_899045.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC163618, AY158090
    Consensus CDS
    CCDS50943.1
    UniProtKB/Swiss-Prot
    E9QLI5, Q68SN8, Q80WN2, Q8BJA5
    UniProtKB/TrEMBL
    J3QJU0
    Related
    ENSMUSP00000142210.2, ENSMUST00000194102.6
    Conserved Domains (4) summary
    cd00096
    Location:133 → 137
    Ig; Ig strand B [structural motif]
    pfam13895
    Location:208 → 290
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:310 → 377
    Ig_3; Immunoglobulin domain
    cl11960
    Location:119 → 202
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87343084..87407985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319623.3 → XP_017175112.1  Fc receptor-like protein 5 isoform X1

    UniProtKB/TrEMBL
    J3QJU0
    Conserved Domains (3) summary
    smart00408
    Location:267 → 328
    IGc2; Immunoglobulin C-2 Type
    pfam13895
    Location:347 → 427
    Ig_2; Immunoglobulin domain
    cl11960
    Location:34 → 112
    Ig; Immunoglobulin domain

  2. XM_006501599.5 → XP_006501662.1  Fc receptor-like protein 5 isoform X2

    Conserved Domains (2) summary
    pfam13895
    Location:208 → 279
    Ig_2; Immunoglobulin domain
    cl11960
    Location:119 → 202
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68SN8.3 GenPept UniProtKB/Swiss-Prot:Q68SN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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