Fcrl5 Fc receptor-like 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcrl5provided by MGI
Official Full Name: Fc receptor-like 5provided by MGI
Primary source: MGI:MGI:3053558
See related: Ensembl:ENSMUSG00000048031 AllianceGenome:MGI:3053558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fcrh3; mBXMH2
Summary: Predicted to enable protein phosphatase binding activity; protein tyrosine kinase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within negative regulation of B cell receptor signaling pathway and negative regulation of release of sequestered calcium ion into cytosol. Located in plasma membrane. Orthologous to several human genes including FCRL5 (Fc receptor like 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 2.7), thymus adult (RPKM 0.2) and 2 other tissues See more
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Genomic context

Location:: 3 F1; 3 38.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87343084..87407985)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87435777..87500678)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease.
Title: Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease.
FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
Title: FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
The three amino-terminal immunoglobulin domains of FCRL5 are required for binding of orthopoxvirus histocompatibility class I-like protein to B cells and monocytes/macrophages.
Title: Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin.
Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.
Title: Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment.
a novel immunoregulatory marker of splenic marginal zone and B1 type B lineage cells.
Title: Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of B cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: Fc receptor-like protein 5

Names: BXMAS1-like protein 2; Fc receptor-like protein 3; fc receptor homolog 3; fcR-like protein 5; moFcRH3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113238.1 → NP_001106709.1 Fc receptor-like protein 5 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC163618, AY158090

Consensus CDS

CCDS50944.1

UniProtKB/TrEMBL

J3QJU0

Related

ENSMUSP00000141311.2, ENSMUST00000193229.6

Conserved Domains (3) summary

smart00410
Location:222 → 305

IG_like; Immunoglobulin like

pfam13895
Location:220 → 303

Ig_2; Immunoglobulin domain

cl11960
Location:31 → 114

Ig; Immunoglobulin domain
NM_183222.3 → NP_899045.3 Fc receptor-like protein 5 isoform a precursor

See identical proteins and their annotated locations for NP_899045.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC163618, AY158090

Consensus CDS

CCDS50943.1

UniProtKB/Swiss-Prot

E9QLI5, Q68SN8, Q80WN2, Q8BJA5

UniProtKB/TrEMBL

J3QJU0

Related

ENSMUSP00000142210.2, ENSMUST00000194102.6

Conserved Domains (4) summary

cd00096
Location:133 → 137

Ig; Ig strand B [structural motif]

pfam13895
Location:208 → 290

Ig_2; Immunoglobulin domain

pfam13927
Location:310 → 377

Ig_3; Immunoglobulin domain

cl11960
Location:119 → 202

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

87343084..87407985

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319623.3 → XP_017175112.1 Fc receptor-like protein 5 isoform X1

UniProtKB/TrEMBL

J3QJU0

Conserved Domains (3) summary

smart00408
Location:267 → 328

IGc2; Immunoglobulin C-2 Type

pfam13895
Location:347 → 427

Ig_2; Immunoglobulin domain

cl11960
Location:34 → 112

Ig; Immunoglobulin domain
XM_006501599.5 → XP_006501662.1 Fc receptor-like protein 5 isoform X2

Conserved Domains (2) summary

pfam13895
Location:208 → 279

Ig_2; Immunoglobulin domain

cl11960
Location:119 → 202

Ig; Immunoglobulin domain