U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316395, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hecw2provided by RGD
Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by RGD
Primary source
RGD:1593244
See related
EnsemblRapid:ENSRNOG00000013257 AllianceGenome:RGD:1593244
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis; regulation of mitotic metaphase/anaphase transition; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitotic spindle. Predicted to be active in cytoplasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 86.0), Lung (RPKM 72.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hecw2 in Genome Data Viewer
Location:
9q31
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (62853904..63247472, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (55359462..55753106, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60451476..60843160, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 7 Neighboring gene uncharacterized LOC120094686 Neighboring gene serine/threonine kinase 17b Neighboring gene uncharacterized LOC134480576 Neighboring gene coiled-coil domain containing 150 Neighboring gene ribosomal protein L31 like 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase HECW2
NP_001101688.1
XP_006244974.1
XP_017451936.1
XP_038939526.1
XP_038939527.1
XP_038939528.1
XP_038939529.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108218.1 → NP_001101688.1  E3 ubiquitin-protein ligase HECW2

    See identical proteins and their annotated locations for NP_001101688.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    A6INZ4, D4ADD3
    Related
    ENSRNOP00000017761.5, ENSRNOT00000017761.7
    Conserved Domains (8) summary
    pfam06390
    Location:464 → 632
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:993 → 1024
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:396 → 741
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1222 → 1576
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam16562
    Location:45 → 162
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:921 → 987
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    62853904..63247472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083599.2 → XP_038939527.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A6INZ4, D4ADD3
    Conserved Domains (8) summary
    pfam06390
    Location:464 → 632
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:993 → 1024
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:396 → 741
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1222 → 1576
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam16562
    Location:45 → 162
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:921 → 987
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  2. XM_017596447.3 → XP_017451936.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A6INZ4, D4ADD3
    Conserved Domains (8) summary
    pfam06390
    Location:464 → 632
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:993 → 1024
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:396 → 741
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1222 → 1576
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam16562
    Location:45 → 162
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:921 → 987
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  3. XM_039083600.2 → XP_038939528.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A6INZ4, D4ADD3
    Conserved Domains (8) summary
    pfam06390
    Location:464 → 632
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:993 → 1024
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:396 → 741
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1222 → 1576
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam16562
    Location:45 → 162
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:921 → 987
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  4. XM_039083598.2 → XP_038939526.1  E3 ubiquitin-protein ligase HECW2 isoform X1

    UniProtKB/TrEMBL
    A6INZ4, D4ADD3
    Conserved Domains (8) summary
    pfam06390
    Location:464 → 632
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:185 → 321
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:993 → 1024
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:396 → 741
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1222 → 1576
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:815 → 844
    WW; WW domain
    pfam16562
    Location:45 → 162
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:921 → 987
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  5. XM_006244912.5 → XP_006244974.1  E3 ubiquitin-protein ligase HECW2 isoform X2

    Conserved Domains (8) summary
    pfam06390
    Location:333 → 501
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:54 → 190
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:862 → 893
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:265 → 610
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1091 → 1445
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:684 → 713
    WW; WW domain
    pfam16562
    Location:1 → 31
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:790 → 856
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

  6. XM_039083601.2 → XP_038939529.1  E3 ubiquitin-protein ligase HECW2 isoform X2

    Conserved Domains (8) summary
    pfam06390
    Location:333 → 501
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08691
    Location:54 → 190
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:862 → 893
    WW; Domain with 2 conserved Trp (W) residues
    COG5271
    Location:265 → 610
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd00078
    Location:1091 → 1445
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:684 → 713
    WW; WW domain
    pfam16562
    Location:1 → 31
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    pfam18436
    Location:790 → 856
    HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous