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Ttk Ttk protein kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315852, updated on 18-Sep-2024

Summary

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Official Symbol
Ttkprovided by RGD
Official Full Name
Ttk protein kinaseprovided by RGD
Primary source
RGD:1305558
See related
EnsemblRapid:ENSRNOG00000029055 AllianceGenome:RGD:1305558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mps1
Summary
Predicted to enable identical protein binding activity; kinetochore binding activity; and protein kinase activity. Predicted to be involved in several processes, including negative regulation of metaphase/anaphase transition of cell cycle; peptidyl-serine phosphorylation; and protein localization to kinetochore. Predicted to act upstream of or within female meiosis chromosome segregation; protein localization to organelle; and protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in kinetochore; nucleus; and spindle. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 91.2), Testes (RPKM 91.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttk in Genome Data Viewer
Location:
8q31
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (93632678..93672664)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (84754329..84792653)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (91368065..91405995)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 like 4 Neighboring gene ELOVL fatty acid elongase 4 Neighboring gene uncharacterized LOC108351756 Neighboring gene uncharacterized LOC102557516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Douville EM, et al. Mol Cell Biol, 1992 Jun. PMID 1375325, Free PMC Article
  2. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Foijer F, et al. Proc Natl Acad Sci U S A, 2014 Sep 16. PMID 25197064, Free PMC Article
  3. Mps1 at kinetochores is essential for female mouse meiosis I. Hached K, et al. Development, 2011 Jun. PMID 21558374
  4. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, et al. Front Immunol, 2022. PMID 35693827, Free PMC Article
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female meiosis chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to meiotic spindle midzone ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in repair of mitotic kinetochore microtubule attachment defect IEA
Inferred from Electronic Annotation
more info
  
involved_in repair of mitotic kinetochore microtubule attachment defect ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein kinase TTK
Names
Monopolar spindle 1
NP_001101642.1
NP_001387981.1
XP_006243522.1
XP_006243523.1
XP_006243524.1
XP_006243525.1
XP_006243526.1
XP_006243527.1
XP_006243528.1
XP_038937454.1
XP_038937455.1
XP_038937456.1
XP_063121625.1
XP_063121627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108172.1 → NP_001101642.1  dual specificity protein kinase TTK isoform 2

    See identical proteins and their annotated locations for NP_001101642.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A6I1S0, A6I1S3
    Related
    ENSRNOP00000079704.1, ENSRNOT00000114297.2
    Conserved Domains (2) summary
    cd14131
    Location:501 → 769
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:503 → 769
    Pkinase; Protein kinase domain

  2. NM_001401052.1 → NP_001387981.1  dual specificity protein kinase TTK isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I1S3, D4A4S7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    93632678..93672664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265555.1 → XP_063121625.1  dual specificity protein kinase TTK isoform X4

    UniProtKB/TrEMBL
    A6I1S3, D4A4S7

  2. XM_006243460.5 → XP_006243522.1  dual specificity protein kinase TTK isoform X1

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (2) summary
    cd14131
    Location:530 → 798
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:532 → 798
    Pkinase; Protein kinase domain

  3. XM_006243461.5 → XP_006243523.1  dual specificity protein kinase TTK isoform X2

    UniProtKB/TrEMBL
    A0A0G2K2S5, A6I1S3
    Related
    ENSRNOP00000042156.4, ENSRNOT00000051612.4
    Conserved Domains (2) summary
    cd14131
    Location:529 → 797
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:531 → 797
    Pkinase; Protein kinase domain

  4. XM_039081527.2 → XP_038937455.1  dual specificity protein kinase TTK isoform X5

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (1) summary
    cd14131
    Location:514 → 782
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

  5. XM_039081528.2 → XP_038937456.1  dual specificity protein kinase TTK isoform X6

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (1) summary
    cd14131
    Location:442 → 710
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

  6. XM_006243463.5 → XP_006243525.1  dual specificity protein kinase TTK isoform X3

    See identical proteins and their annotated locations for XP_006243525.1

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (2) summary
    cd14131
    Location:519 → 787
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:521 → 787
    Pkinase; Protein kinase domain

  7. XM_039081526.2 → XP_038937454.1  dual specificity protein kinase TTK isoform X4

    UniProtKB/TrEMBL
    A6I1S3, D4A4S7
    Conserved Domains (1) summary
    cd14131
    Location:518 → 786
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

  8. XM_006243465.5 → XP_006243527.1  dual specificity protein kinase TTK isoform X3

    See identical proteins and their annotated locations for XP_006243527.1

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (2) summary
    cd14131
    Location:519 → 787
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:521 → 787
    Pkinase; Protein kinase domain

  9. XM_063265557.1 → XP_063121627.1  dual specificity protein kinase TTK isoform X4

    UniProtKB/TrEMBL
    A6I1S3, D4A4S7

  10. XM_006243462.5 → XP_006243524.1  dual specificity protein kinase TTK isoform X3

    See identical proteins and their annotated locations for XP_006243524.1

    UniProtKB/TrEMBL
    A6I1S3
    Related
    ENSRNOP00000072355.2, ENSRNOT00000083151.3
    Conserved Domains (2) summary
    cd14131
    Location:519 → 787
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:521 → 787
    Pkinase; Protein kinase domain

  11. XM_006243464.5 → XP_006243526.1  dual specificity protein kinase TTK isoform X3

    See identical proteins and their annotated locations for XP_006243526.1

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (2) summary
    cd14131
    Location:519 → 787
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:521 → 787
    Pkinase; Protein kinase domain

  12. XM_006243466.4 → XP_006243528.1  dual specificity protein kinase TTK isoform X3

    See identical proteins and their annotated locations for XP_006243528.1

    UniProtKB/TrEMBL
    A6I1S3
    Conserved Domains (2) summary
    cd14131
    Location:519 → 787
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:521 → 787
    Pkinase; Protein kinase domain
Nucleotide Protein Strain
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