U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgap32 Rho GTPase activating protein 32 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315530, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Arhgap32provided by RGD
Official Full Name
Rho GTPase activating protein 32provided by RGD
Primary source
RGD:1305267
See related
EnsemblRapid:ENSRNOG00000008709 AllianceGenome:RGD:1305267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Grit; Rics; p250GAP
Summary
Predicted to enable GTPase activator activity. Involved in cerebellum development; positive regulation of axon extension; and positive regulation of neuron migration. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ARHGAP32 (Rho GTPase activating protein 32). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 113.0), Adrenal (RPKM 69.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arhgap32 in Genome Data Viewer
Location:
8q21
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38679368..38939960)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30421269..30681653)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33131874..33392198)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 7 Neighboring gene ribosomal protein S19 like 2 Neighboring gene lactate dehydrogenase A like 1 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like Neighboring gene uncharacterized LOC134480155 Neighboring gene ribosomal protein L35 like 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Myo9b and RICS modulate dendritic morphology of cortical neurons. Long H, et al. Cereb Cortex, 2013 Jan. PMID 22250289
  2. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. Kannan M, et al. PLoS One, 2012. PMID 23226367, Free PMC Article
  3. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. Moon SY, et al. J Biol Chem, 2003 Feb 7. PMID 12454018
  4. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
  5. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. Okabe T, et al. J Biol Chem, 2003 Mar 14. PMID 12531901

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data demonstrate that Myo9b and RICS repress RhoA/Rock signaling and modulate dendritic morphogenesis in cortical neurons
    Title: Myo9b and RICS modulate dendritic morphology of cortical neurons.
  2. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases
    Title: RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
  3. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases.
    Title: RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho GTPase-activating protein 32

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427098.1 → NP_001414027.1  rho GTPase-activating protein 32

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6GIC6
    Related
    ENSRNOP00000099101.1, ENSRNOT00000173150.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    38679368..38939960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265405.1 → XP_063121475.1  rho GTPase-activating protein 32 isoform X9

    UniProtKB/TrEMBL
    A0A8I5Y6H2

  2. XM_017595999.3 → XP_017451488.1  rho GTPase-activating protein 32 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GFW8, A0A8I6GIC6
    Conserved Domains (3) summary
    cd07298
    Location:101 → 215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237 → 290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342 → 536
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

  3. XM_063265400.1 → XP_063121470.1  rho GTPase-activating protein 32 isoform X1

    Related
    ENSRNOP00000112297.1, ENSRNOT00000170083.1

  4. XM_063265401.1 → XP_063121471.1  rho GTPase-activating protein 32 isoform X2

    Related
    ENSRNOP00000089744.2, ENSRNOT00000099034.2

  5. XM_017595997.3 → XP_017451486.3  rho GTPase-activating protein 32 isoform X5

  6. XM_063265404.1 → XP_063121474.1  rho GTPase-activating protein 32 isoform X6

  7. XM_063265406.1 → XP_063121476.1  rho GTPase-activating protein 32 isoform X12

  8. XM_063265402.1 → XP_063121472.1  rho GTPase-activating protein 32 isoform X3

    UniProtKB/TrEMBL
    F1MAK3
    Related
    ENSRNOP00000088168.2, ENSRNOT00000119263.2

  9. XM_017595996.3 → XP_017451485.1  rho GTPase-activating protein 32 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GFW8

  10. XM_008766074.4 → XP_008764296.1  rho GTPase-activating protein 32 isoform X7

    See identical proteins and their annotated locations for XP_008764296.1

    UniProtKB/TrEMBL
    A0A8I6GFW8
    Conserved Domains (3) summary
    cd07298
    Location:127 → 241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263 → 316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368 → 562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  11. XM_006242777.5 → XP_006242839.1  rho GTPase-activating protein 32 isoform X10

    See identical proteins and their annotated locations for XP_006242839.1

    UniProtKB/TrEMBL
    A0A8I6GFW8
    Conserved Domains (3) summary
    cd11835
    Location:50 → 103
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:155 → 349
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:1 → 28
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  12. XM_039082294.2 → XP_038938222.1  rho GTPase-activating protein 32 isoform X11

    UniProtKB/TrEMBL
    B5DEI5
    Related
    ENSRNOP00000011589.6, ENSRNOT00000011589.8
    Conserved Domains (1) summary
    cd04384
    Location:19 → 213
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous