Tjp3 tight junction protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tjp3provided by RGD
Official Full Name: tight junction protein 3provided by RGD
Primary source: RGD:1309247
See related: EnsemblRapid:ENSRNOG00000020501 AllianceGenome:RGD:1309247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to act upstream of or within regulation of G1/S transition of mitotic cell cycle. Located in cell-cell junction. Orthologous to human TJP3 (tight junction protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 38.6), Kidney (RPKM 29.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9078757..9097003)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8427650..8446279)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11295892..11314535)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131893 (e-PCR)
- UniSTS:215176

RH128401 (e-PCR)
- UniSTS:211709

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tight junction protein ZO-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108073.1 → NP_001101543.1 tight junction protein ZO-3

See identical proteins and their annotated locations for NP_001101543.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K898, D3Z8G7

Conserved Domains (4) summary

smart00072
Location:585 → 761

GuKc; Guanylate kinase homologues

cd00992
Location:15 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:616 → 760

Guanylate_kin; Guanylate kinase

cl17036
Location:469 → 542

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9078757..9097003

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240933.5 → XP_006240995.1 tight junction protein ZO-3 isoform X2

See identical proteins and their annotated locations for XP_006240995.1

UniProtKB/TrEMBL

A6K899, D3Z8G7

Conserved Domains (4) summary

smart00072
Location:580 → 756

GuKc; Guanylate kinase homologues

cd00992
Location:10 → 90

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:611 → 755

Guanylate_kin; Guanylate kinase

cl17036
Location:464 → 537

SH3; Src Homology 3 domain superfamily
XM_039079017.2 → XP_038934945.1 tight junction protein ZO-3 isoform X1

UniProtKB/TrEMBL

A0A0G2K8M3, D3Z8G7

Related

ENSRNOP00000027847.6, ENSRNOT00000027847.7

Conserved Domains (3) summary

smart00072
Location:589 → 765

GuKc; Guanylate kinase homologues

cd00992
Location:19 → 99

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17036
Location:473 → 546

SH3; Src Homology 3 domain superfamily