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Ift74 intraflagellar transport 74 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313365, updated on 18-Sep-2024

Summary

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Official Symbol
Ift74provided by RGD
Official Full Name
intraflagellar transport 74provided by RGD
Primary source
RGD:1359704
See related
EnsemblRapid:ENSRNOG00000008075 AllianceGenome:RGD:1359704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc2
Summary
Predicted to enable beta-tubulin binding activity and chromatin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly. Predicted to act upstream of or within several processes, including keratinocyte development; non-motile cilium assembly; and positive regulation of cell adhesion mediated by integrin. Predicted to be located in nucleus. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22. Orthologous to human IFT74 (intraflagellar transport 74). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 325.8), Brain (RPKM 66.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift74 in Genome Data Viewer
Location:
5q33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114576106..114679581)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109460372..109563839)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113579065..113682485)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102920 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene phospholipase A2, activating protein Neighboring gene leucine rich repeat containing 19 Neighboring gene microRNA 872 Neighboring gene TEK receptor tyrosine kinase Neighboring gene equatorin Neighboring gene myb-like, SWIRM and MPN domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells. Fujino RS, et al. Mol Reprod Dev, 2006 Aug. PMID 16705683
  2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Bhogaraju S, et al. Science, 2013 Aug 30. PMID 23990561, Free PMC Article
  3. Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin and integrin-alpha family genes in mouse spermatocyte-derived cells. Ichiro Ohbayashi K, et al. Genes Cells, 2010 Jun. PMID 20545763
  4. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. Bell SE, et al. J Cell Sci, 2001 Aug. PMID 11683410
  5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94371

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 74 homolog
Names
coiled-coil domain containing 2
intraflagellar transport 74 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007001.1 → NP_001007002.1  intraflagellar transport protein 74 homolog

    See identical proteins and their annotated locations for NP_001007002.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083611
    UniProtKB/TrEMBL
    F7FIM8, Q5XIR2
    Related
    ENSRNOP00000011336.3, ENSRNOT00000011336.6
    Conserved Domains (2) summary
    COG1196
    Location:219 → 590
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21341
    Location:7 → 63
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    114576106..114679581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593367.3 → XP_017448856.1  intraflagellar transport protein 74 homolog isoform X1

    UniProtKB/TrEMBL
    F7FIM8, Q5XIR2
    Conserved Domains (2) summary
    COG1196
    Location:219 → 590
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd21341
    Location:7 → 63
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

  2. XM_063287637.1 → XP_063143707.1  intraflagellar transport protein 74 homolog isoform X2

  3. XM_039109896.2 → XP_038965824.1  intraflagellar transport protein 74 homolog isoform X3

    Conserved Domains (1) summary
    COG1196
    Location:99 → 470
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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