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Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311952, updated on 10-Oct-2024

Summary

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Official Symbol
Galnt11provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 11provided by RGD
Primary source
RGD:735097
See related
EnsemblRapid:ENSRNOG00000008117 AllianceGenome:RGD:735097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in several processes, including Notch signaling involved in heart development; cellular protein metabolic process; and regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 770.7), Liver (RPKM 164.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galnt11 in Genome Data Viewer
Location:
4q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (10571464..10604974, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (9837629..9871141, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6297255..6330765, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486540 Neighboring gene lysine methyltransferase 2C Neighboring gene microtubule-associated protein 1 light chain 3 beta, pseudogene 2 Neighboring gene ribosomal protein L30, pseudogene 8 Neighboring gene polypeptide N-acetylgalactosaminyltransferase-like 5 Neighboring gene calcineurin B homologous protein 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. Boskovski MT, et al. Nature, 2013 Dec 19. PMID 24226769, Free PMC Article
  2. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables Notch binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Notch receptor processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in determination of left/right symmetry ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 11
Names
:polypeptide N-acetylgalactosaminyltransferase 11
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
galNAc-T11
polypeptide GalNAc transferase 11
pp-GaNTase 11
protein-UDP acetylgalactosaminyltransferase 11
NP_001258248.1
NP_955425.2
XP_006235985.1
XP_063142010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271319.1 → NP_001258248.1  polypeptide N-acetylgalactosaminyltransferase 11

    See identical proteins and their annotated locations for NP_001258248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6P6V1
    UniProtKB/TrEMBL
    A0A0H2UHG8, A6KJI6
    Related
    ENSRNOP00000011815.4, ENSRNOT00000011814.9
    Conserved Domains (4) summary
    cd02510
    Location:155 → 453
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:488 → 607
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:484 → 605
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:155 → 383
    Glyco_tranf_2_3; Glycosyltransferase like family 2

  2. NM_199393.2 → NP_955425.2  polypeptide N-acetylgalactosaminyltransferase 11

    See identical proteins and their annotated locations for NP_955425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC062004, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6P6V1
    UniProtKB/TrEMBL
    A0A0H2UHG8, A6KJI6
    Conserved Domains (4) summary
    cd02510
    Location:155 → 453
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:488 → 607
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:484 → 605
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:155 → 383
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    10571464..10604974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235923.5 → XP_006235985.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X1

    See identical proteins and their annotated locations for XP_006235985.1

    UniProtKB/Swiss-Prot
    Q6P6V1
    UniProtKB/TrEMBL
    A0A0H2UHG8, A6KJI6
    Conserved Domains (4) summary
    cd02510
    Location:155 → 453
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:488 → 607
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:484 → 605
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:155 → 383
    Glyco_tranf_2_3; Glycosyltransferase like family 2

  2. XM_063285940.1 → XP_063142010.1  polypeptide N-acetylgalactosaminyltransferase 11 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6V1.1 GenPept UniProtKB/Swiss-Prot:Q6P6V1

Gene LinkOut

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