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Rassf2 Ras association domain family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311437, updated on 10-Oct-2024

Summary

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Official Symbol
Rassf2provided by RGD
Official Full Name
Ras association domain family member 2provided by RGD
Primary source
RGD:1305551
See related
EnsemblRapid:ENSRNOG00000021261 AllianceGenome:RGD:1305551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of protein kinase activity; protein stabilization; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade; negative regulation of NIK/NF-kappaB signaling; and regulation of protein phosphorylation. Predicted to be located in several cellular components, including Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RASSF2 (Ras association domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 145.9), Thymus (RPKM 119.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rassf2 in Genome Data Viewer
Location:
3q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (139697187..139733402, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119244288..119280462, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (124574088..124610267, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486157 Neighboring gene prion protein Neighboring gene prion like protein doppel Neighboring gene uncharacterized LOC134486447 Neighboring gene uncharacterized LOC102552722 Neighboring gene solute carrier family 23 member 2 Neighboring gene choline/ethanolamine kinase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Cooper WN, et al. Oncogene, 2009 Aug 20. PMID 19525978, Free PMC Article
  2. Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. Song H, et al. EMBO J, 2012 Mar 7. PMID 22227519, Free PMC Article
  3. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Song H, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19962960
  4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124713

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 2
Names
Ras association (RalGDS/AF-6) domain family 2
Ras association (RalGDS/AF-6) domain family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037096.2 → NP_001032173.2  ras association domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q3B7D5
    UniProtKB/TrEMBL
    A6HQF2, G3V8W1
    Related
    ENSRNOP00000028883.7, ENSRNOT00000028883.9
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:278 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    139697187..139733402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283783.1 → XP_063139853.1  ras association domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HQF2, G3V8W1

  2. XM_006235066.4 → XP_006235128.1  ras association domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006235128.1

    UniProtKB/Swiss-Prot
    Q3B7D5
    UniProtKB/TrEMBL
    A6HQF2, G3V8W1
    Conserved Domains (2) summary
    cd17221
    Location:177 → 263
    RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
    pfam16517
    Location:278 → 316
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RNA

  1. XR_005501884.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7D5.1 GenPept UniProtKB/Swiss-Prot:Q3B7D5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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