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Ppip5k1 diphosphoinositol pentakisphosphate kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311355, updated on 10-Oct-2024

Summary

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Official Symbol
Ppip5k1provided by RGD
Official Full Name
diphosphoinositol pentakisphosphate kinase 1provided by RGD
Primary source
RGD:1311552
See related
EnsemblRapid:ENSRNOG00000014436 AllianceGenome:RGD:1311552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hisppd2a; RGD1311552
Summary
Predicted to enable ATP binding activity and phosphotransferase activity, phosphate group as acceptor. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 58.1), Kidney (RPKM 51.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppip5k1 in Genome Data Viewer
Location:
3q35
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128737857..128781408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108284120..108327683, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113272850..113316324, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule-associated protein 1A Neighboring gene creatine kinase, mitochondrial 1 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene protein disulfide isomerase family A, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. Choi JH, et al. J Biol Chem, 2007 Oct 19. PMID 17702752, Free PMC Article
  2. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Mulugu S, et al. Science, 2007 Apr 6. PMID 17412958
  3. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. Fridy PC, et al. J Biol Chem, 2007 Oct 19. PMID 17690096
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables diphosphoinositol pentakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol hexakisphosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Names
PP-IP5 kinase 1
VIP1 homolog
histidine acid phosphatase domain containing 2A
histidine acid phosphatase domain-containing protein 2A
insP6 and PP-IP5 kinase 1
NP_001074252.1
XP_006234900.1
XP_006234902.1
XP_008760392.1
XP_017447227.1
XP_038960885.1
XP_038960886.1
XP_038960892.1
XP_038960893.1
XP_038960894.1
XP_063139788.1
XP_063139789.1
XP_063139790.1
XP_063139791.1
XP_063139792.1
XP_063139793.1
XP_063139794.1
XP_063139795.1
XP_063139796.1
XP_063139797.1
XP_063139799.1
XP_063139800.1
XP_063139801.1
XP_063139802.1
XP_063139803.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080783.2 → NP_001074252.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

    See identical proteins and their annotated locations for NP_001074252.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P0C644
    Related
    ENSRNOP00000096590.2, ENSRNOT00000114684.2
    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128737857..128781408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234838.5 → XP_006234900.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006234900.1

    UniProtKB/Swiss-Prot
    P0C644
    UniProtKB/TrEMBL
    A0A8I6AQ26
    Related
    ENSRNOP00000095887.1, ENSRNOT00000115690.2
    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  2. XM_006234840.5 → XP_006234902.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006234902.1

    UniProtKB/Swiss-Prot
    P0C644
    UniProtKB/TrEMBL
    A0A8I6AQ26
    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  3. XM_039104957.2 → XP_038960885.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P0C644
    UniProtKB/TrEMBL
    A0A8I6AQ26
    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  4. XM_039104958.2 → XP_038960886.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P0C644
    UniProtKB/TrEMBL
    A0A8I6AQ26
    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  5. XM_063283719.1 → XP_063139789.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

  6. XM_063283731.1 → XP_063139801.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X14

  7. XM_063283725.1 → XP_063139795.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  8. XM_063283729.1 → XP_063139799.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X12

  9. XM_063283723.1 → XP_063139793.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

  10. XM_063283720.1 → XP_063139790.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AVA5

  11. XM_063283722.1 → XP_063139792.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

  12. XM_063283718.1 → XP_063139788.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQK2

  13. XM_063283730.1 → XP_063139800.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X13

  14. XM_063283727.1 → XP_063139797.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

  15. XM_063283726.1 → XP_063139796.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2K4M9
    Related
    ENSRNOP00000073104.2, ENSRNOT00000091665.3

  16. XM_063283724.1 → XP_063139794.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AB72
    Related
    ENSRNOP00000090965.1, ENSRNOT00000119490.2

  17. XM_063283721.1 → XP_063139791.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

    UniProtKB/TrEMBL
    F1LSW6
    Related
    ENSRNOP00000059430.2, ENSRNOT00000065285.4

  18. XM_063283732.1 → XP_063139802.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X16

  19. XM_008762170.2 → XP_008760392.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X15

    UniProtKB/TrEMBL
    A6HPN5
    Conserved Domains (1) summary
    pfam00328
    Location:135 → 651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  20. XM_017591738.3 → XP_017447227.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X17

  21. XM_039104964.2 → XP_038960892.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X18

    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  22. XM_039104965.2 → XP_038960893.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X19

    Conserved Domains (2) summary
    pfam00328
    Location:392 → 908
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  23. XM_039104966.2 → XP_038960894.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X20

    Conserved Domains (2) summary
    pfam00328
    Location:392 → 809
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:57 → 146
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  24. XM_063283733.1 → XP_063139803.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X21

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C644.1 GenPept UniProtKB/Swiss-Prot:P0C644

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