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Arhgap1 Rho GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311193, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap1provided by RGD
Official Full Name
Rho GTPase activating protein 1provided by RGD
Primary source
RGD:1306068
See related
EnsemblRapid:ENSRNOG00000016610 AllianceGenome:RGD:1306068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of endocytic recycling; small GTPase-mediated signal transduction; and transferrin transport. Located in perinuclear region of cytoplasm. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 250.8), Heart (RPKM 143.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap1 in Genome Data Viewer
Location:
3q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98077064..98099163)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77621377..77643400)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80555196..80576881)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene transfer RNA alanine (anticodon AGC) 76 Neighboring gene coagulation factor II, thrombin Neighboring gene zinc finger protein 408 Neighboring gene autophagy related 13 Neighboring gene harbinger transposase derived 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rho GTPase‑activating protein 1 promotes apoptosis of myocardial cells in an ischemic cardiomyopathy model. Zhang X, et al. Kardiol Pol, 2019 Dec 19. PMID 31664016
  2. IGFBP-5(201-218) stimulates Cdc42GAP aggregation and filopodia formationin migrating mesangial cells. Berfield AK, et al. Kidney Int, 2000 May. PMID 10792618
  3. Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. Lancaster CA, et al. J Biol Chem, 1994 Jan 14. PMID 8288572
  4. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Wang L, et al. Proc Natl Acad Sci U S A, 2007 Jan 23. PMID 17227869, Free PMC Article
  5. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. Barfod ET, et al. J Biol Chem, 1993 Dec 15. PMID 8253717

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in sorting endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107747.2 → NP_001101217.2  rho GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001101217.2

    Status: VALIDATED

    Source sequence(s)
    AA900696, CK480577, CO573331, DN932805, DV725096, EV768858
    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    98077064..98099163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104900.2 → XP_038960828.1  rho GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. XM_006234551.4 → XP_006234613.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234613.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Related
    ENSRNOP00000059324.1, ENSRNOT00000067318.5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. XM_006234560.4 → XP_006234622.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234622.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Related
    ENSRNOP00000070761.3, ENSRNOT00000079118.3
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  4. XM_006234556.4 → XP_006234618.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234618.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. XM_039104901.2 → XP_038960829.1  rho GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  6. XM_006234554.4 → XP_006234616.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234616.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  7. XM_006234558.5 → XP_006234620.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234620.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  8. XM_006234552.5 → XP_006234614.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234614.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  9. XM_006234557.5 → XP_006234619.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234619.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  10. XM_017591716.3 → XP_017447205.1  rho GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  11. XM_006234553.5 → XP_006234615.1  rho GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006234615.1

    UniProtKB/TrEMBL
    A0A8I6A7T6, D4A6C5
    Conserved Domains (2) summary
    cd04404
    Location:239 → 431
    RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
    pfam13716
    Location:82 → 216
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  12. XM_006234559.4 → XP_006234621.1  rho GTPase-activating protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7T6
    Conserved Domains (2) summary
    cd04404
    Location:165 → 357
    RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...
    pfam13716
    Location:8 → 132
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein Strain
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