Mef2a myocyte enhancer factor 2a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mef2aprovided by RGD
Official Full Name: myocyte enhancer factor 2aprovided by RGD
Primary source: RGD:1359360
See related: EnsemblRapid:ENSRNOG00000047756 AllianceGenome:RGD:1359360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including cellular response to calcium ion; cellular response to glucose stimulus; and dendrite morphogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 399.7), Lung (RPKM 276.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (130258083..130392819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (120847874..120982488, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (128207715..128341681, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise increases MEF2A abundance in rat cardiac muscle by downregulating microRNA-223-5p.
Title: Exercise increases MEF2A abundance in rat cardiac muscle by downregulating microRNA-223-5p.
Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5.
Title: Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5.
These data demonstrate a novel MEF2A-dependent mechanism for the regulation of activity-dependent AMPA receptors trafficking.
Title: MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.
the present study reveals a previously unknown OTR-coupled MAPK-MEF-2A pathway, which is responsible for oxytocin-induced neurite retraction of hypothalamic neurons.
Title: Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A).
MEF2A participates in neuronal differentiation/maturation from neural stem cells.
Title: The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons.
MEF2A is a transcriptional regulator for Capn3 gene expression.
Title: MEF2A regulates Calpain 3 expression in L6 myoblasts.
MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process.
Title: Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors.
Animal physical conditioning increases hyper-acetylation of histones and increased the expression of NRF-1 and MEF2A genes.
Title: Exercise increases hyper-acetylation of histones on the Cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes.
microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A
Title: MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
MEF2 regulates basal Mfn2 expression in neurons and that excitotoxicity-dependent degradation of MEF2 causes Mfn2 downregulation. Thus, Mfn2 reduction is a late event in excitotoxicity.
Title: Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

Mef2a (e-PCR), detects polymorphism
- UniSTS:265599

Mef2a (e-PCR), detects polymorphism
- UniSTS:265600

BF390775 (e-PCR)
- UniSTS:249553

AU048441 (e-PCR)
- UniSTS:144891

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in ERK5 cascade	IEA Inferred from Electronic Annotation more info
involved_in ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in ERK5 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion distribution	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion distribution	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac myofibril assembly	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myocyte-specific enhancer factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014035.2 → NP_001014057.1 myocyte-specific enhancer factor 2A

See identical proteins and their annotated locations for NP_001014057.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

Related

ENSRNOP00000068690.3, ENSRNOT00000089723.3

Conserved Domains (3) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam11597
Location:129 → 238

Med13_N; Mediator complex subunit 13 N-terminal

pfam12347
Location:98 → 152

HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

130258083..130392819 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080825.2 → XP_038936753.1 myocyte-specific enhancer factor 2A isoform X1

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

A0A0G2JSZ4, D8X2M2

Related

ENSRNOP00000064552.2, ENSRNOT00000072915.4

Conserved Domains (3) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:129 → 380

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_039080839.2 → XP_038936767.1 myocyte-specific enhancer factor 2A isoform X2

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

A0A8I6AYJ3, A6JBR9

Related

ENSRNOP00000094055.1, ENSRNOT00000113672.2

Conserved Domains (3) summary

COG5068
Location:1 → 235

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:125 → 378

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_063265624.1 → XP_063121694.1 myocyte-specific enhancer factor 2A isoform X6
XM_039080833.2 → XP_038936761.1 myocyte-specific enhancer factor 2A isoform X1

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

A0A0G2JSZ4, D8X2M2

Conserved Domains (3) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:129 → 380

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063265619.1 → XP_063121689.1 myocyte-specific enhancer factor 2A isoform X5
XM_063265595.1 → XP_063121665.1 myocyte-specific enhancer factor 2A isoform X2

UniProtKB/TrEMBL

A0A8I6AYJ3, A6JBR9
XM_063265611.1 → XP_063121681.1 myocyte-specific enhancer factor 2A isoform X4
XM_063265617.1 → XP_063121687.1 myocyte-specific enhancer factor 2A isoform X3

UniProtKB/TrEMBL

M0R6R7

Related

ENSRNOP00000065122.2, ENSRNOT00000070864.5
XM_008759541.4 → XP_008757763.1 myocyte-specific enhancer factor 2A isoform X3

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

M0R6R7

Conserved Domains (3) summary

COG5068
Location:1 → 235

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:125 → 370

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_039080830.2 → XP_038936758.1 myocyte-specific enhancer factor 2A isoform X1

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

A0A0G2JSZ4, D8X2M2

Conserved Domains (3) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:129 → 380

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063265606.1 → XP_063121676.1 myocyte-specific enhancer factor 2A isoform X4
XM_039080843.2 → XP_038936771.1 myocyte-specific enhancer factor 2A isoform X3

UniProtKB/Swiss-Prot

Q2MJT0, Q66HD7

UniProtKB/TrEMBL

M0R6R7

Conserved Domains (3) summary

COG5068
Location:1 → 235

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam05109
Location:125 → 370

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)