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Trpm3 transient receptor potential cation channel, subfamily M, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309407, updated on 2-Nov-2024

Summary

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Official Symbol
Trpm3provided by RGD
Official Full Name
transient receptor potential cation channel, subfamily M, member 3provided by RGD
Primary source
RGD:1304888
See related
EnsemblRapid:ENSRNOG00000027770 AllianceGenome:RGD:1304888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to act upstream of or within monoatomic cation transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cataract. Orthologous to human TRPM3 (transient receptor potential cation channel subfamily M member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 121.3), Testes (RPKM 18.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Trpm3 in Genome Data Viewer
Location:
1q51
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (229099741..229984172)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (219673200..220557610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (239741572..240757583)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS17-like Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 7 Neighboring gene cell migration inducing hyaluronidase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene ubiquitin-conjugating enzyme E2 D2-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134483976 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 3 Neighboring gene uncharacterized LOC134483978 Neighboring gene uncharacterized LOC108349823 Neighboring gene uncharacterized LOC102552001 Neighboring gene microRNA 204 Neighboring gene uncharacterized LOC134483977 Neighboring gene 40S ribosomal protein S12-like Neighboring gene uncharacterized LOC108349100

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons. Langen KR, et al. Auton Neurosci, 2023 Jul. PMID 37146443, Free PMC Article
  2. Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis. Zhao M, et al. Pain, 2022 Nov 1. PMID 35413036
  3. Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions. Ohashi K, et al. Biol Pharm Bull, 2021. PMID 33518671
  4. TRPM3 expression and control of glutamate release from primary vagal afferent neurons. Ragozzino FJ, et al. J Neurophysiol, 2021 Jan 1. PMID 33296617, Free PMC Article
  5. Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats. Zamudio-Bulcock PA, et al. J Neurochem, 2011 Nov. PMID 21955047, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons.
    Title: Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons.
  2. Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis.
    Title: Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis.
  3. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line INS-1.
    Title: Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.
  4. TRPM3 expression and control of glutamate release from primary vagal afferent neurons.
    Title: TRPM3 expression and control of glutamate release from primary vagal afferent neurons.
  5. Zn(2+) ions inhibit gene transcription following stimulation of the Ca(2+) channels Cav1.2 and TRPM3.
    Title: Zn(2+) ions inhibit gene transcription following stimulation of the Ca(2+) channels Ca(v)1.2 and TRPM3.
  6. Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions.
    Title: Transient Receptor Potential Melastatin 3 Is Functionally Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic Demyelinated Lesions.
  7. Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels.
    Title: Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels.
  8. Expression of TRPM3 or depolarization of insulinoma cells is required to connect pregnenolone sulfate stimulation with enhanced gene transcription.
    Title: Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels.
  9. Polymerase chain reaction used to check the expression of all TRPM and TRPV channel members with specific primers.
    Title: Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat.
  10. TRPM3 channels are novel modulators of glutamatergic transmission in the neonatal cerebellar cortex.
    Title: Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191562.1 → NP_001178491.1  transient receptor potential cation channel subfamily M member 3 isoform a

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A0P1
    Related
    ENSRNOP00000084148.1, ENSRNOT00000109194.2
    Conserved Domains (1) summary
    pfam16519
    Location:1233 → 1284
    TRPM_tetra; Tetramerization domain of TRPM

  2. NM_001354180.1 → NP_001341109.1  transient receptor potential cation channel subfamily M member 3 isoform b

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ALW5, F1LN45
    Related
    ENSRNOP00000018521.8, ENSRNOT00000018521.8
    Conserved Domains (2) summary
    pfam16519
    Location:1231 → 1282
    TRPM_tetra; Tetramerisation domain of TRPM
    cl26777
    Location:869 → 1199
    TRP_2; Transient receptor ion channel II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    229099741..229984172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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