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Mctp2 multiple C2 and transmembrane domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308742, updated on 17-Aug-2024

Summary

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Official Symbol
Mctp2provided by RGD
Official Full Name
multiple C2 and transmembrane domain containing 2provided by RGD
Primary source
RGD:1562967
See related
EnsemblRapid:ENSRNOG00000009932 AllianceGenome:RGD:1562967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562967
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of membrane. Orthologous to human MCTP2 (multiple C2 and transmembrane domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 62.4), Lung (RPKM 31.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mctp2 in Genome Data Viewer
Location:
1q31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (135179845..135412798, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (125769932..126002886, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (133324881..133559644, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099851 Neighboring gene uncharacterized LOC134485136 Neighboring gene uncharacterized LOC134485135 Neighboring gene uncharacterized LOC134485137 Neighboring gene spermatogenesis-associated protein 13-like Neighboring gene transfer RNA alanine (anticodon AGC) 79

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. Shin OH, et al. J Biol Chem, 2005 Jan 14. PMID 15528213
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
multiple C2 and transmembrane domain-containing protein 2
Names
multiple C2 domains, transmembrane 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191625.2 → NP_001178554.1  multiple C2 and transmembrane domain-containing protein 2

    See identical proteins and their annotated locations for NP_001178554.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A096MKH3, D4A733
    Related
    ENSRNOP00000068515.2, ENSRNOT00000077049.3
    Conserved Domains (4) summary
    cd04042
    Location:189 → 308
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:351 → 463
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:503 → 621
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:765 → 818
    PRT_C; Plant phosphoribosyltransferase C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    135179845..135412798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589163.3 → XP_017444652.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

  2. XM_008759526.3 → XP_008757748.2  multiple C2 and transmembrane domain-containing protein 2 isoform X3

  3. XM_039112926.2 → XP_038968854.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    cd08377
    Location:77 → 195
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:339 → 392
    PRT_C; Plant phosphoribosyltransferase C-terminal
    cl14603
    Location:3 → 37
    C2; C2 domain

  4. XM_017589162.3 → XP_017444651.2  multiple C2 and transmembrane domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D4A733
    Conserved Domains (3) summary
    cd04042
    Location:189 → 308
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:351 → 463
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:503 → 621
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

RNA

  1. XR_005505581.2 RNA Sequence

  2. XR_005505582.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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